Seco[D-Asp3]microcystin-RR and [D-Asp3,D-Glu(OMe)6]microcystin-RR, two new microcystins from a toxic water bloom of the cyanobacterium Planktothrix rubescens

被引：28
作者：
Grach-Pogrebinsky, O
Sedmak, B
Carmeli, S [1 ]
机构：
[1] Tel Aviv Univ, Sch Chem, Raymond & Beverly Sackler Fac Exact Sci, IL-69978 Tel Aviv, Israel
[2] Natl Inst Biol, Ljubljana 1001, Slovenia
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 03期
关键词：
D O I：
10.1021/np034036r
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two novel microcystins, seco[D-Asp(3)]microcystin-RR (1) and [D-Asp(3),D-Glu(OMe)(6)]-microcystin-RR (2), along with the known [D-Asp(3)]microcystin-RR (3), were isolated from a Planktothrix rubescens toxic bloom collected in Lake Bled, Slovenia. The structures were deduced using one- and two-dimensional NMR techniques, ESIMS/CID/MS analysis, and Marfey's method for determining the amino acids' absolute stereochemistry. Compounds I and 3 exhibit weak PP1 inhibitory activity. The NMR data of compound 3 are reported here for the first time.
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页码：337 / 342
页数：6
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