The application of nanomaterials in controlled drug delivery for bone regeneration

被引：33

作者：

Shi, Shuo ^{[1
]}

Jiang, Wenbao ^{[2
]}

Zhao, Tianxiao ^{[3
]}

Aifantis, Katerina E. ^{[4
]}

Wang, Hui ^{[1
]}

Lin, Lei ^{[1
]}

Fan, Yubo ^{[3
]}

Feng, Qingling ^{[5
]}

Cui, Fu-zhai ^{[5
]}

Li, Xiaoming

机构：

[1] Hebei Med Univ, Dept Orthoped, Hosp 1, Shijiazhuang 050031, Peoples R China

[2] Zhangbei Hosp, Dept Gen Surg, Zhangbei 076450, Peoples R China

[3] Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mechanobiol, Beijing 100191, Peoples R China

[4] Univ Arizona, Dept Civil Engn Engn Mech, Tucson, AZ 85721 USA

[5] Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2015年 / 103卷 / 12期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

nanomaterials; controlled drug delivery; bone regeneration; IN-VIVO BIODISTRIBUTION; CONTROLLED-RELEASE; CARBON NANOTUBES; MORPHOGENETIC PROTEIN-2; SILICA NANOPARTICLES; BIOACTIVE MOLECULES; TISSUE REGENERATION; PARATHYROID-HORMONE; TITANIA NANOTUBES; GROWTH-FACTOR;

D O I：

10.1002/jbm.a.35522

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by controlled drug delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in controlled drug delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in controlled drug delivery for bone regeneration are reviewed and discussed, which indicates that the controlling drug delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in controlled drug delivery for bone regeneration are described in the conclusion and perspectives part. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3978-3992, 2015.

引用

页码：3978 / 3992

页数：15

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