Spectroscopy of single hemoglobin molecules by surface enhanced Raman scattering

被引：2176
|
作者：
Xu, HX [1 ]
Bjerneld, EJ [1 ]
Käll, M [1 ]
Börjesson, L [1 ]
机构：
[1] Chalmers, Dept Appl Phys, S-41296 Gothenburg, Sweden
来源：
PHYSICAL REVIEW LETTERS | 1999年 / 83卷 / 21期
关键词：
D O I：
10.1103/PhysRevLett.83.4357
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
We demonstrate the detection of molecular vibrations in single hemoglobin (Hb) protein molecules attached to isolated and immobilized silver nanoparticles by surface enhanced Raman scattering (SERS). A comparison between calculation and experiment indicates that electromagnetic field effects dominate the surface enhancement, and that single molecule Hb SERS is possible only for molecules situated between Ag particles. The vibrational spectra exhibit temporal fluctuations of unknown origin which appear to be characteristic of the single molecule detection limit.
引用
收藏
页码：4357 / 4360
页数：4
相关论文
共 50 条
  • [41] Rapid Glucose Detection by Surface Enhanced Raman Scattering Spectroscopy
    Yang, Lanying
    Du, Chunlei
    Luo, Xiangang
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 9 (04) : 2660 - 2663
  • [42] Single-Molecule Imaging and Spectroscopy Using Fluorescence and Surface-Enhanced Raman Scattering
    M. Ishikawa
    Y. Maruyama
    J.-Y. Ye
    M. Futamata
    Journal of Biological Physics, 2002, 28 : 573 - 585
  • [43] Surface-enhanced Raman scattering spectroscopy of sialosides and their derivatives
    Feofanov, AV
    Oleinikov, VA
    Tuzikov, AB
    Ianoul, AI
    Kryukov, EY
    Sokolov, KV
    Bovin, NV
    Nabiev, IR
    BIOORGANICHESKAYA KHIMIYA, 1996, 22 (09): : 706 - 716
  • [44] Molecular spectroscopy workbench, surface-enhanced Raman scattering
    Adar, Fran
    SPECTROSCOPY, 2008, 23 (02) : 20 - +
  • [45] APPLICATIONS OF RAMAN AND SURFACE-ENHANCED RAMAN-SCATTERING SPECTROSCOPY IN MEDICINE
    NABIEV, I
    CHOURPA, I
    MANFAIT, M
    JOURNAL OF RAMAN SPECTROSCOPY, 1994, 25 (01) : 13 - 23
  • [46] THE ROLE OF SURFACTANTS IN THE SURFACE ENHANCED RAMAN-SCATTERING SPECTROSCOPY
    MATEJKA, P
    CHEMICKE LISTY, 1992, 86 (12): : 875 - 883
  • [47] Polarised Raman spectroscopy on a single class of single-wall nanotubes by nano surface-enhanced scattering
    Azoulay, J
    Débarre, A
    Richard, A
    Tchénio, P
    Bandow, S
    Iijima, S
    CHEMICAL PHYSICS LETTERS, 2000, 331 (5-6) : 347 - 353
  • [48] Enhanced Raman Scattering by Polystyrene Microspheres and Application for Detecting Molecules Adsorbed on Au Single Crystal Surface
    Lin Xiu-Mei
    Wang Xiang
    Liu Zheng
    Ren Bin
    ACTA PHYSICO-CHIMICA SINICA, 2008, 24 (11) : 1941 - 1944
  • [49] Levy statistics of vibrational mode fluctuations of single molecules from surface-enhanced raman scattering
    Bizzarri, AR
    Cannistraro, S
    PHYSICAL REVIEW LETTERS, 2005, 94 (06)
  • [50] ENHANCED RAMAN-SCATTERING BY MOLECULES ADSORBED AT THE SURFACE OF COLLOIDAL SPHEROIDS
    WANG, DS
    KERKER, M
    PHYSICAL REVIEW B, 1981, 24 (04) : 1777 - 1790
12345