MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case-control study and meta-analysis

被引：7
|
作者：
Haerian, Monir Sadat [1 ]
Haerian, Batoul Sadat [2 ]
Molanaei, Saadat [3 ]
Kosari, Farid [4 ]
Sabeti, Shahram [5 ]
Bidari-Zerehpoosh, Farahnaz [5 ]
Abdolali, Ebrahim [6 ]
Zali, Mohammad Reza [7 ]
机构：
[1] Iran Univ Med Sci, Shafa Yahyaeian Orthoped Hosp, Bone & Joint Reconstruct Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran
[3] Milad Hosp, Dept Pathol, Tehran, Iran
[4] Univ Tehran Med Sci, Sina Hosp, Dept Pathol, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Pathol, Tehran, Iran
[6] Shahid Beheshti Univ Med Sci, Taleghani Hosp, Dept Pathol, Tehran, Iran
[7] Shahid Beheshti Univ Med Sci, GLDRC, Tehran, Iran
来源：
PHARMACOGENOMICS | 2016年 / 17卷 / 17期
关键词：
colorectal cancer; meta-analysis; MTHFR; polymorphism; susceptibility; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; A1298C POLYMORPHISMS; DNA-DAMAGE; RISK; FOLATE; ASSOCIATION; HOMOCYSTEINE; METHYLATION; DEFICIENCY; GENES;
D O I：
10.2217/pgs-2016-0048
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive. Aim: The purpose of this study was to investigate this hypothesis in a case-control study and meta-analysis in Iranian population. Materials & methods: This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC. Results: Both case-control study and meta-analysis showed no association between rs1801133 and CRC risk or its features. Conclusion: This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population.
引用
收藏
页码：1957 / 1965
页数：9
相关论文
共 50 条
  • [31] Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: An update meta-analysis based on 51 research studies
    Yu, Liwa
    Chen, Jianqiu
    DIAGNOSTIC PATHOLOGY, 2012, 7
  • [32] Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach
    Purnomo, Athaya Febriantyo
    Daryanto, Besut
    Seputra, Kurnia Penta
    Budaya, Taufiq Nur
    Lutfiana, Nurul Cholifah
    Nurkolis, Fahrul
    Chung, Sanghyun
    Suh, Jin Young
    Park, Moon Nyeo
    Seo, Byung-Kwan
    Kim, Bonglee
    CANCERS, 2023, 15 (17)
  • [33] Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis
    Sun, Manyi
    Zhong, Jin
    Zhang, Li
    Shi, Songli
    BMC MEDICAL GENETICS, 2019, 20
  • [34] Lack of association between MTHFR C677T Gene polymorphism with alcohol dependence: A meta-analysis of case-control studies
    Xu, Rong
    Wu, Hao
    Zhang, Shiying
    Zhou, Heng
    Liang, Liang
    NEUROSCIENCE LETTERS, 2018, 683 : 69 - 74
  • [35] Survivin rs9904341 polymorphism significantly increased the risk of cancer: evidence from an updated meta-analysis of case-control studies
    Moazeni-Roodi, Abdolkarim
    Ghavami, Saeid
    Hashemi, Mohammad
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2019, 24 (04) : 335 - 349
  • [36] Association of XRCC3 gene rs861539 polymorphism with gastric cancer risk: evidence from a case-control study and a meta-analysis
    Cheng, Shidan
    Wang, Liying
    Wang, Lei
    Wang, Zhengting
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (02): : 1911 - 1919
  • [37] Association of methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C>T) gene polymorphism with ischemic stroke risk in different populations: An updated meta-analysis
    Zhao, Lili
    Li, Tao
    Dang, Meijuan
    Li, Ye
    Fan, Hong
    Hao, Qian
    Song, Dingli
    Lu, Jialiang
    Lu, Ziwei
    Jian, Yating
    Wang, Heying
    Wang, Xiaoya
    Wu, Yulun
    Zhang, Guilian
    FRONTIERS IN GENETICS, 2023, 13
  • [38] Association between rs735482 polymorphism and risk of cancer: A meta-analysis of 10 case-control studies
    Xue, Shilin
    Shen, Wenya
    Cai, Jianning
    Jia, Jinhai
    Zhao, Dan
    Zhang, Shan
    Zhao, Xiujun
    Ma, Ning
    Wang, Wenjuan
    Wang, Bingshuang
    Zhang, Xiaolin
    Liu, Xuehui
    MEDICINE, 2022, 101 (30) : E29318
  • [39] The CYP19A1 rs700519 Polymorphism and Breast Cancer Susceptibility in China: A Case-Control Study and Updated Meta-Analysis
    Lv, Fei
    Huang, Wanying
    Wang, Ying
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2021, 25 (07) : 486 - 495
  • [40] An evidence-based approach to globally assess the covariate-dependent effect of the MTHFR single nucleotide polymorphism rs1801133 on blood homocysteine: a systematic review and meta-analysis
    Jin, Huifeng
    Cheng, Haojie
    Chen, Wei
    Sheng, Xiaoming
    Levy, Mark A.
    Brown, Mark J.
    Tian, Junqiang
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2018, 107 (05) : 817 - 825
12345