MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case-control study and meta-analysis

被引：7
|
作者：
Haerian, Monir Sadat [1 ]
Haerian, Batoul Sadat [2 ]
Molanaei, Saadat [3 ]
Kosari, Farid [4 ]
Sabeti, Shahram [5 ]
Bidari-Zerehpoosh, Farahnaz [5 ]
Abdolali, Ebrahim [6 ]
Zali, Mohammad Reza [7 ]
机构：
[1] Iran Univ Med Sci, Shafa Yahyaeian Orthoped Hosp, Bone & Joint Reconstruct Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran
[3] Milad Hosp, Dept Pathol, Tehran, Iran
[4] Univ Tehran Med Sci, Sina Hosp, Dept Pathol, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Pathol, Tehran, Iran
[6] Shahid Beheshti Univ Med Sci, Taleghani Hosp, Dept Pathol, Tehran, Iran
[7] Shahid Beheshti Univ Med Sci, GLDRC, Tehran, Iran
来源：
PHARMACOGENOMICS | 2016年 / 17卷 / 17期
关键词：
colorectal cancer; meta-analysis; MTHFR; polymorphism; susceptibility; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; A1298C POLYMORPHISMS; DNA-DAMAGE; RISK; FOLATE; ASSOCIATION; HOMOCYSTEINE; METHYLATION; DEFICIENCY; GENES;
D O I：
10.2217/pgs-2016-0048
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive. Aim: The purpose of this study was to investigate this hypothesis in a case-control study and meta-analysis in Iranian population. Materials & methods: This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC. Results: Both case-control study and meta-analysis showed no association between rs1801133 and CRC risk or its features. Conclusion: This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population.
引用
收藏
页码：1957 / 1965
页数：9
相关论文
共 50 条
  • [31] Association between the TERT rs2736100 polymorphism and lung cancer risk: evidence from a case-control study and a meta-analysis
    Ding, Yipeng
    Du, Shuli
    Sun, Pei
    Niu, Huan
    Duan, Mengling
    Jin, Tianbo
    Yao, Hongxia
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (06): : 5818 - 5827
  • [32] The CYP19A1 rs700519 Polymorphism and Breast Cancer Susceptibility in China: A Case-Control Study and Updated Meta-Analysis
    Lv, Fei
    Huang, Wanying
    Wang, Ying
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2021, 25 (07) : 486 - 495
  • [33] Association of methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C>T) gene polymorphism with ischemic stroke risk in different populations: An updated meta-analysis
    Zhao, Lili
    Li, Tao
    Dang, Meijuan
    Li, Ye
    Fan, Hong
    Hao, Qian
    Song, Dingli
    Lu, Jialiang
    Lu, Ziwei
    Jian, Yating
    Wang, Heying
    Wang, Xiaoya
    Wu, Yulun
    Zhang, Guilian
    FRONTIERS IN GENETICS, 2023, 13
  • [34] MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies
    Sheng, Xuewen
    Zhang, Yanxi
    Zhao, Erjiang
    Lu, Su
    Zheng, Xiaoli
    Ge, Hong
    Lu, Weiquan
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (10) : 9669 - 9679
  • [35] Association of PPARG rs 1801282 C>G polymorphism with risk of colorectal cancer: from a case-control study to a meta-analysis
    Jiang, Jiakai
    Xie, Zhiqiang
    Guo, JunYing
    Wang, Yafeng
    Liu, Chao
    Zhang, Sheng
    Tang, Weifeng
    Chen, Yu
    ONCOTARGET, 2017, 8 (59) : 100558 - 100569
  • [36] MTHFR polymorphism and the risk of prostate cancer: a meta-analysis of case–control studies
    X-L Li
    J-H Xu
    Prostate Cancer and Prostatic Diseases, 2012, 15 : 244 - 249
  • [37] Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case–control study of colorectal cancer
    Xueren Gao
    Shulong Zhang
    Zhansheng Zhu
    Molecular Genetics and Genomics, 2015, 290 : 23 - 28
  • [38] Association of rs4516035 Polymorphism with Osteoporosis in the Southeastern Iranian Population: A Case-Control Study
    Yaghoobi, Mohammad Mehdi
    Gholami, Azadeh Samare
    JOURNAL OF RESEARCH IN HEALTH SCIENCES, 2024, 24 (01)
  • [39] Association of 677 C>T (rs1801133) and 1298 A>C (rs1801131) Polymorphisms in the MTHFR Gene and Breast Cancer Susceptibility: A Meta-Analysis Based on 57 Individual Studies
    Li, Kai
    Li, Wusheng
    Dong, Xi
    PLOS ONE, 2014, 9 (06):
  • [40] Association of MTHFR 677C>T polymorphism with breast cancer risk: A case-control study and meta-analysis
    Lal, Harmesh
    Sharma, Bhavna
    Sambyal, Vasudha
    Guleria, Kamlesh
    Singh, Neeti Rajan
    Uppal, Manjit Singh
    Manjari, Mridu
    Sudan, Meena
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2022, 18 (06) : 1451 - +
12345