MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case-control study and meta-analysis

被引：7

作者：

Haerian, Monir Sadat ^{[1
]}

Haerian, Batoul Sadat ^{[2
]}

Molanaei, Saadat ^{[3
]}

Kosari, Farid ^{[4
]}

Sabeti, Shahram ^{[5
]}

Bidari-Zerehpoosh, Farahnaz ^{[5
]}

Abdolali, Ebrahim ^{[6
]}

Zali, Mohammad Reza ^{[7
]}

机构：

[1] Iran Univ Med Sci, Shafa Yahyaeian Orthoped Hosp, Bone & Joint Reconstruct Res Ctr, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran

[3] Milad Hosp, Dept Pathol, Tehran, Iran

[4] Univ Tehran Med Sci, Sina Hosp, Dept Pathol, Tehran, Iran

[5] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Pathol, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Taleghani Hosp, Dept Pathol, Tehran, Iran

[7] Shahid Beheshti Univ Med Sci, GLDRC, Tehran, Iran

来源：

PHARMACOGENOMICS | 2016年 / 17卷 / 17期

关键词：

colorectal cancer; meta-analysis; MTHFR; polymorphism; susceptibility; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; A1298C POLYMORPHISMS; DNA-DAMAGE; RISK; FOLATE; ASSOCIATION; HOMOCYSTEINE; METHYLATION; DEFICIENCY; GENES;

D O I：

10.2217/pgs-2016-0048

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive. Aim: The purpose of this study was to investigate this hypothesis in a case-control study and meta-analysis in Iranian population. Materials & methods: This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC. Results: Both case-control study and meta-analysis showed no association between rs1801133 and CRC risk or its features. Conclusion: This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population.

引用

页码：1957 / 1965

页数：9

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