MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case-control study and meta-analysis

被引：7
作者：
Haerian, Monir Sadat [1 ]
Haerian, Batoul Sadat [2 ]
Molanaei, Saadat [3 ]
Kosari, Farid [4 ]
Sabeti, Shahram [5 ]
Bidari-Zerehpoosh, Farahnaz [5 ]
Abdolali, Ebrahim [6 ]
Zali, Mohammad Reza [7 ]
机构：
[1] Iran Univ Med Sci, Shafa Yahyaeian Orthoped Hosp, Bone & Joint Reconstruct Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran
[3] Milad Hosp, Dept Pathol, Tehran, Iran
[4] Univ Tehran Med Sci, Sina Hosp, Dept Pathol, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Pathol, Tehran, Iran
[6] Shahid Beheshti Univ Med Sci, Taleghani Hosp, Dept Pathol, Tehran, Iran
[7] Shahid Beheshti Univ Med Sci, GLDRC, Tehran, Iran
来源：
PHARMACOGENOMICS | 2016年 / 17卷 / 17期
关键词：
colorectal cancer; meta-analysis; MTHFR; polymorphism; susceptibility; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; A1298C POLYMORPHISMS; DNA-DAMAGE; RISK; FOLATE; ASSOCIATION; HOMOCYSTEINE; METHYLATION; DEFICIENCY; GENES;
D O I：
10.2217/pgs-2016-0048
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive. Aim: The purpose of this study was to investigate this hypothesis in a case-control study and meta-analysis in Iranian population. Materials & methods: This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC. Results: Both case-control study and meta-analysis showed no association between rs1801133 and CRC risk or its features. Conclusion: This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population.
引用
收藏
页码：1957 / 1965
页数：9
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