Lifestyle Modifications in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

被引：19

作者：

Stavropoulos, Konstantinos ^{[1
]}

Imprialos, Konstantinos ^{[1
]}

Pittaras, Andreas ^{[2
,3
]}

Faselis, Charles ^{[2
,3
]}

Narayan, Puneet ^{[2
,3
]}

Kokkinos, Peter ^{[2
,3
]}

机构：

[1] Aristotle Univ Thessaloniki, Propaedeut Dept Med 2, Thessaloniki, Greece

[2] VAMC, Washington, DC USA

[3] Georgetown Univ, Sch Med, Washington, DC 20057 USA

来源：

CURRENT VASCULAR PHARMACOLOGY | 2018年 / 16卷 / 03期

关键词：

Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; lifestyle modification; weight loss; physical activity; nutrition; diet; CORONARY-HEART-DISEASE; LEFT-VENTRICULAR HYPERTROPHY; BODY-MASS INDEX; PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; EXERCISE CAPACITY; WEIGHT-LOSS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; RISK-FACTORS;

D O I：

10.2174/1570161115666170621080835

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide, affecting more than 30% of general population. High-fat diets, physical inactivity and obesity, all prevalent in the western societies, are strongly associated with the development and progression of NAFLD. Current drug therapies have not consistently shown substantial beneficial effects. Thus, lifestyle modification appears to be the optimal intervention in combating the disease. Accordingly, several studies have concluded that weight loss, via increase in physical activity, and dietary interventions could potential ameliorate biochemical, histological, and structural abnormalities of non-alcoholic fatty liver disease. The aim of this review is to summarize the findings of these lifestyle intervention studies and discuss the implementation of each intervention, and its effectiveness in the management of the disease in everyday clinical practice.

引用

页码：239 / 245

页数：7

共 89 条

[1] The natural history of nonalcoholic fatty liver disease: A population-based cohort study [J].

Adams, LA ;

Lymp, JF ;

St Sauver, J ;

Sanderson, SO ;

Lindor, KD ;

Feldstein, A ;

Angulo, P .

GASTROENTEROLOGY, 2005, 129 (01) :113-121

[2] Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis [J].

Angulo, P ;

Keach, JC ;

Batts, KP ;

Lindor, KD .

HEPATOLOGY, 1999, 30 (06) :1356-1362

[3] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[4] The use of statins alone, or in combination with pioglitazone and other drugs, for the treatment of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and related cardiovascular risk. An Expert Panel Statement [J].

Athyros, Vasilios G. ;

Alexandrides, Theodore K. ;

Bilianou, Helen ;

Cholongitas, Evangelos ;

Doumas, Michael ;

Ganotakis, Emmanuel S. ;

Goudevenos, John ;

Elisaf, Moses S. ;

Germanidis, Georgios ;

Giouleme, Olga ;

Karagiannis, Asterios ;

Karvounis, Charalambos ;

Katsiki, Niki ;

Kotsis, Vasilios ;

Kountouras, Jannis ;

Liberopoulos, Evangelos ;

Pitsavos, Christos ;

Polyzos, Stergios ;

Rallidis, Loukianos S. ;

Richter, Dimitrios ;

Tsapas, Apostolos G. ;

Tselepis, Alexandros D. ;

Tsioufis, Konstantinos ;

Tziomalos, Konstantinos ;

Tzotzas, Themistoklis ;

Vasiliadis, Themistoklis G. ;

Vlachopoulos, Charalambos ;

Mikhailidis, Dimitri P. ;

Mantzoros, Christos .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2017, 71 :17-32

[5] Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: an update [J].

Athyros, Vasilios G. ;

Tziomalos, Konstantinos ;

Katsiki, Niki ;

Doumas, Michael ;

Karagiannis, Asterios ;

Mikhailidis, Dimitri P. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (22) :6820-6834

[6] Both Resistance Training and Aerobic Training Reduce Hepatic Fat Content in Type 2 Diabetic Subjects With Nonalcoholic Fatty Liver Disease (the RAED2 Randomized Trial) [J].

Bacchi, Elisabetta ;

Negri, Carlo ;

Targher, Giovanni ;

Faccioli, Niccolo ;

Lanza, Massimo ;

Zoppini, Giacomo ;

Zanolin, Elisabetta ;

Schena, Federico ;

Bonora, Enzo ;

Moghetti, Paolo .

HEPATOLOGY, 2013, 58 (04) :1287-1295

[7] Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos Nutrition and Liver Study [J].

Bedogni, G ;

Miglioli, L ;

Masutti, F ;

Tiribelli, C ;

Marchesini, G ;

Bellentani, S .

HEPATOLOGY, 2005, 42 (01) :44-52

[8]

Bedogni Giorgio, 2004, Ann Hepatol, V3, P63

[9] High- or Low-Carbohydrate Diets: Which Is Better for Weight Loss, Insulin Resistance, and Fatty Livers? [J].

Boden, Guenther .

GASTROENTEROLOGY, 2009, 136 (05) :1490-1492

[10] The Impact of Cardiorespiratory Fitness Levels on the Risk of Developing Atherogenic Dyslipidemia [J].

Breneman, Charity B. ;

Polinski, Kristen ;

Sarzynski, Mark A. ;

Lavie, Carl J. ;

Kokkinos, Peter F. ;

Ahmed, Ali ;

Sui, Xuemei .

AMERICAN JOURNAL OF MEDICINE, 2016, 129 (10) :1060-1066

← 1 2 3 4 5 6 7 8 9 →