The Active Role of Leguminous Plant Components in Type 2 Diabetes

被引:25
作者
Getek, Monika [1 ]
Czech, Natalia [1 ]
Muc-Wierzgon, Malgorzata [1 ]
Grochowska-Niedworok, Elzbieta [2 ]
Kokot, Teresa [1 ]
Nowakowska-Zajdel, Ewa [1 ]
机构
[1] Silesian Med Univ, Dept Internal Med, PL-41902 Katowice, Poland
[2] Silesian Med Univ, Dept Human Nutr, PL-41808 Katowice, Poland
关键词
BEANS VIGNA-ANGULARIS; PHASEOLUS-VULGARIS; ALPHA-GLUCOSIDASE; FOOD-INTAKE; HYPERGLYCEMIA; GENISTEIN; EXTRACTS; PROTEIN; LUPIN; PURIFICATION;
D O I
10.1155/2014/293961
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Diabetes appears to be one of the most frequent noncommunicable diseases in the world. A permanent growth in the incidence of diabetes can be observed and according to the International Diabetes Federation (IDF) the year 2030 will mark the increase in the number of diabetics to 439 mln worldwide. Type 2 diabetes accounts for about 90% of all diabetes incidence. Nutrition model modification not only features the basic element in type 2 diabetes treatment but also constitutes the fundamental factor influencing a morbidity rate decrease. Leguminous plants are a key factor in the diabetic diet; plants such as pulses or soybeans are nutritious products valued highly in nutrition. These legumes are high in the content of wholesome protein and contain large amounts of soluble alimentary fiber fractions, polyunsaturated fatty acids, vitamins and minerals, and bioactive substances with antioxidant, anti-inflammatory, and anticancer activity. They are distinguished by the high amount of bioactive compounds that may interfere with the metabolism of glucose. The most significant bioactive compounds displaying antidiabetic activity in leguminous plants are as follows: genistein and daidzein, alpha-amylase inhibitors, and alpha-glucosidase inhibitors. In vitro research using leguminous plant extracts has confirmed their antidiabetic properties. Leguminous plants should be employed in the promotion of healthy lifestyles in terms of functional food.
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页数:12
相关论文
共 61 条
[11]   Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice [J].
Choi, M. S. ;
Jung, U. J. ;
Yeo, J. ;
Kim, M. J. ;
Lee, M. K. .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2008, 24 (01) :74-81
[12]   Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition [J].
Choo, C. Y. ;
Sulong, N. Y. ;
Man, F. ;
Wong, T. W. .
JOURNAL OF ETHNOPHARMACOLOGY, 2012, 142 (03) :776-781
[13]   Bioavailability of the Polyphenols: Status and Controversies [J].
D'Archivio, Massimo ;
Filesi, Carmelina ;
Vari, Rosaria ;
Scazzocchio, Beatrice ;
Masella, Roberta .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (04) :1321-1342
[14]   Lupin and soya reduce glycaemia acutely in type 2 diabetes [J].
Dove, Emma R. ;
Mori, Trevor A. ;
Chew, Gerard T. ;
Barden, Anne E. ;
Woodman, Richard J. ;
Puddey, Ian B. ;
Sipsas, Sofia ;
Hodgson, Jonathan M. .
BRITISH JOURNAL OF NUTRITION, 2011, 106 (07) :1045-1051
[15]   Grain legume proteins and nutraceutical properties [J].
Duranti, M .
FITOTERAPIA, 2006, 77 (02) :67-82
[16]   Reducing Effect of a Phaseolus vulgaris Dry Extract on Food Intake, Body Weight, and Glycemia in Rats [J].
Fantini, Noemi ;
Cabras, Claudia ;
Lobina, Carla ;
Colombo, Giancarlo ;
Gessa, Gian Luigi ;
Riva, Antonella ;
Donzelli, Fabio ;
Morazzoni, Paolo ;
Bombardelli, Ezio ;
Carai, Mauro A. M. .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (19) :9316-9323
[17]  
Fu Z, 2012, APPL PHYSIOL NUTR ME, V37, P480, DOI [10.1139/h2012-005, 10.1139/H2012-005]
[18]   Long-term exposure to genistein improves insulin secretory function of pancreatic β-cells [J].
Fu, Zhuo ;
Liu, Dongmin .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 616 (1-3) :321-327
[19]   Soya protein does not affect glycaemic control in adults with type 2 diabetes [J].
Gobert, Colleen P. ;
Pipe, Elizabeth A. ;
Capes, Sarah E. ;
Darlington, Gerarda A. ;
Lampe, Johanna W. ;
Duncan, Alison M. .
BRITISH JOURNAL OF NUTRITION, 2010, 103 (03) :412-421
[20]  
Gornicka M., 2011, BROMATOLOGIA CHEM TO, V4, P1034