Eugenol has attracted considerable attention because of its potential for many pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant properties. Here, we have investigated the effect of eugenol on amyloid formation of selected globular proteins. We find that both spontaneous and seed-induced aggregation processes of insulin and serum albumin (BSA) are significantly suppressed in the presence of eugenol. Isothermal titration calorimetric data predict a single binding site for eugenol-insulin complex confirming the affinity of eugenol for native soluble insulin species. We also find that eugenol suppresses amyloid-induced hemolysis. Our findings reveal the inherent ability of eugenol to stabilize native proteins and to delay the conversion of protein species of native conformation into beta-sheet assembled mature fibrils, which seems to be crucial for its inhibitory effect.
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Chinnathambi, Shanmugavel
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Velmurugan, Devadasan
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Hanagata, Nobutaka
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Natl Inst Mat Sci, Nanotechnol Innovat Stn, Tsukuba, Ibaraki 3050047, Japan
Hokkaido Univ, Grad Sch Life Sci, Kita Ku, Sapporo, Hokkaido 0600812, JapanAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Hanagata, Nobutaka
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Aruna, Prakasa Rao
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Aruna, Prakasa Rao
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Ganesan, Singaravelu
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Chinnathambi, Shanmugavel
;
论文数: 引用数:
h-index:
机构:
Velmurugan, Devadasan
;
Hanagata, Nobutaka
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Mat Sci, Nanotechnol Innovat Stn, Tsukuba, Ibaraki 3050047, Japan
Hokkaido Univ, Grad Sch Life Sci, Kita Ku, Sapporo, Hokkaido 0600812, JapanAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Hanagata, Nobutaka
;
Aruna, Prakasa Rao
论文数: 0引用数: 0
h-index: 0
机构:
Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Aruna, Prakasa Rao
;
Ganesan, Singaravelu
论文数: 0引用数: 0
h-index: 0
机构:
Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India