Correspondence Humoral response after the booster dose of anti-SARS-CoV-2 vaccine in multiple sclerosis patients treated with high-efficacy therapies

被引：15
|
作者：
Maglione, Alessandro [1 ]
Morra, Marta [1 ]
Meroni, Raffaella [1 ]
Matta, Manuela [1 ]
Clerico, Marinella [1 ]
Rolla, Simona [1 ]
机构：
[1] Univ Turin, Dept Clin & Biol Sci, Turin, Italy
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2022年 / 61卷
关键词：
Multiple sclerosis; Anti-SARS-Cov2; vaccine; Booster; Third dose;
D O I：
10.1016/j.msard.2022.103776
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Anti-SARS-CoV2 mRNA vaccines showed a blunted antibody (Ab) response in people with MS (pwMS) on high efficacy therapies, suggesting the need for a booster dose. We evaluated the kinetics of the production of antireceptor binding domain (RBD) Immunoglobulins G (IgG) after the vaccination cycle and the booster in pwMS receiving ocrelizumab, fingolimod and cladribine. A significant increase of anti-RBD IgG seroconversion was observed after booster respect to the vaccination cycle. Results obtained from this study will be useful for the management of pwMS in relation to their disease modifying therapy (DMT) and for any future vaccination campaign.
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