Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance

被引：39

作者：

Nezhad-Mokhtari, Parinaz ^{[1
,2
]}

Ghorbani, Marjan ^{[3
]}

Abdyazdani, Nima ^{[3
]}

机构：

[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran

[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[3] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 167卷

关键词：

Scaffold; Guar gum; Zein nanoparticle; SILK FIBROIN; TISSUE; NANOFIBERS; MORPHOLOGY;

D O I：

10.1016/j.ijbiomac.2020.11.103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 +/- 1.09 mm) and E. coli (11.54 +/- 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application. (C) 2020 Published by Elsevier B.V.

引用

页码：59 / 65

页数：7

共 43 条

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