The Prognostic Role of Circulating Tumor Cells (CTCs) in Lung Cancer

被引：99

作者：

Kapeleris, Joanna ^{[1
,2
]}

Kulasinghe, Arutha ^{[1
,2
]}

Warkiani, Majid E. ^{[3
,4
]}

Vela, Ian ^{[5
,6
]}

Kenny, Liz ^{[7
]}

O' Byrne, Kenneth ^{[1
,2
,8
]}

Punyadeera, Chamindie ^{[1
,2
]}

机构：

[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Kelvin Grove, Qld, Australia

[2] Translat Res Inst, Brisbane, Qld, Australia

[3] Univ Technol Sydney, Sch Biomed Engn, Sydney, NSW, Australia

[4] IM Sechenov First Moscow State Med Univ, Inst Mol Med, Moscow, Russia

[5] Princess Alexandra Hosp, Dept Urol, Woolloongabba, Qld, Australia

[6] Queensland Univ Technol, Australian Prostate Canc Res Ctr, Inst Hlth & Biomed Innovat, Translat Res Inst,Princess Alexandra Hosp, Brisbane, Qld, Australia

[7] Univ Queensland, Royal Brisbane & Womens Hosp, Sch Med, Cent Integrated Reg Canc Serv,Queensland Hlth, Brisbane, Qld, Australia

[8] Princess Alexandra Hosp, Queensland Hlth, Brisbane, Qld, Australia

来源：

FRONTIERS IN ONCOLOGY | 2018年 / 8卷

关键词：

lung cancer; NSCLC; SCLC; Circulating tumor cells; liquid biopsy; PROGRESSION-FREE SURVIVAL; CLINICAL-SIGNIFICANCE; BREAST-CANCER; PERIPHERAL-BLOOD; MUTATIONAL ANALYSIS; MOLECULAR ANALYSIS; PROSTATE-CANCER; PULMONARY VEIN; CHEMOTHERAPY; EGFR;

D O I：

10.3389/fonc.2018.00311

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer affects over 1.8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include "liquid biopsies" through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting.

引用

页数：13

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