Cancer and aging: The molecular pathways

被引：8

作者：

Bassi, PierFrancesco ^{[1
]}

Sacco, Emilio ^{[1
]}

机构：

[1] Catholic Univ, Sch Med, Dept Urol, Agostino Gemelli Hosp, Rome, Italy

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2009年 / 27卷 / 06期

关键词：

Aging; Cancer; Telomere; Senescence; Apoptosis; Oxidative stress; Stem cell; MITOTIC CHECKPOINT GENES; LIFE-SPAN; OXIDATIVE STRESS; STEM-CELLS; SUPEROXIDE-DISMUTASE; MICE DEFICIENT; DNA-DAMAGE; FIBROBLASTS; CATALASE; OXYGEN;

D O I：

10.1016/j.urolonc.2009.07.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A growing amount of experimental evidences has progressively shown that aging and carcinogenesis share many molecular pathways. During aging, the accumulation of genetic and epigenetic changes, the diminishing of telomere length, the progressive disruption of mechanisms for DNA damage repair, glucose metabolism regulation, cell cycle control, and stem cells self-renewal lead to induction of senescence or apoptosis and loss of replicative capacity. The same cellular dysfunctional mechanisms characterizing the aging process have been found to be involved, with different level of evidence, in cancerogenesis and are reviewed herein. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：620 / 627

页数：8

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