Expression of Peg1 (Mest) in the developing mouse heart:: Involvement in trabeculation

被引:34
作者
King, T
Bland, Y
Webb, S
Barton, S
Brown, NA
机构
[1] Univ London St Georges Hosp, Sch Med, Dept Anat & Dev Biol, London SW17 ORE, England
[2] Wellcome Trust Canc Res UK, Inst Canc & Dev Biol, Cambridge, England
关键词
Peg1; Mest; trabeculae; heart; myocardium; atrial appendage; pectinate muscles; left right asymmetry ventricles; noncompaction; imprinting;
D O I
10.1002/dvdy.10142
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Peg1 (Mest) is an imprinted gene of unknown function widely expressed in the mouse embryo, predominantly in cells of the mesodermal lineage. We have revealed a restricted expression pattern within the developing heart. Initial uniform expression throughout the linear heart tube subsequently becomes restricted, primarily to the developing myocardial trabeculae of both the atria and ventricles, where it persists into late development. Expression in the atrial appendage myocardium precedes the emergence of trabeculae (pectinate muscles), and occurs earlier and to a greater extent on the right than on the left, reflecting the spatial and temporal pattern of trabeculation. Analysis of myocardial morphology in mice lacking the Peg1 gene, which are viable and appear grossly normal, reveals a subtle alteration in the pattern of trabeculation: an increase in thickness and reduction in density of the compact myocardium, similar to that seen in the human cardiomyopathy ventricular noncompaction. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:212 / 215
页数:4
相关论文
共 10 条
  • [1] EXPRESSION OF A DELTA-HOMOLOG IN PROSPECTIVE NEURONS IN THE CHICK
    HENRIQUE, D
    ADAM, J
    MYAT, A
    CHITNIS, A
    LEWIS, J
    ISHHOROWICZ, D
    [J]. NATURE, 1995, 375 (6534) : 787 - 790
  • [2] Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy
    Jenni, R
    Oechslin, E
    Schneider, J
    Jost, CA
    Kaufmann, PA
    [J]. HEART, 2001, 86 (06) : 666 - 671
  • [3] PEG1/MEST IMPRINTED GENE ON CHROMOSOME-6 IDENTIFIED BY CDNA SUBTRACTION HYBRIDIZATION
    KANEKOISHINO, T
    KUROIWA, Y
    MIYOSHI, N
    KOHDA, T
    SUZUKI, R
    YOKOYAMA, M
    VIVILLE, S
    BARTON, SC
    ISHINO, F
    SURANI, MA
    [J]. NATURE GENETICS, 1995, 11 (01) : 52 - 59
  • [4] Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest
    Lefebvre, L
    Viville, S
    Barton, SC
    Ishino, F
    Keverne, EB
    Surani, MA
    [J]. NATURE GENETICS, 1998, 20 (02) : 163 - 169
  • [5] Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ
    Mikawa, T
    Gourdie, RG
    [J]. DEVELOPMENTAL BIOLOGY, 1996, 174 (02) : 221 - 232
  • [6] Sensitive nonradioactive detection of mRNA in tissue sections: Novel application of the whole-mount in situ hybridization protocol
    Moorman, AFM
    Houweling, AC
    de Boer, PAJ
    Christoffels, VM
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2001, 49 (01) : 1 - 8
  • [7] SADO T, 1993, DEV GROWTH DIFFER, V35, P551, DOI 10.1111/j.1440-169X.1993.00551.x
  • [8] Sedmera D, 2000, ANAT RECORD, V258, P319, DOI 10.1002/(SICI)1097-0185(20000401)258:4<319::AID-AR1>3.0.CO
  • [9] 2-O
  • [10] Formation of the atrioventricular septal structures in the normal mouse
    Webb, S
    Brown, NA
    Anderson, RH
    [J]. CIRCULATION RESEARCH, 1998, 82 (06) : 645 - 656