共 62 条
Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog
被引:55
作者:
Chang, W. L. William
[1
]
Barry, Peter A.
[1
]
Szubin, Richard
[1
,2
]
Wang, Dai
[3
]
Baumgarth, Nicole
[1
,2
]
机构:
[1] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA
[2] Univ Calif San Francisco, Sch Dent, Dept Cell & Tissue Biol, San Francisco, CA 94154 USA
[3] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
来源:
基金:
美国国家卫生研究院;
关键词:
Human cytomegalovirus;
Interleukin;
10;
Type I interferons;
Plasmacytoid dendritic cells;
CD8(+) T-CELLS;
REGULATORY FACTOR-3;
B-CELLS;
DIFFERENTIAL REGULATION;
INHIBITS MATURATION;
POSITIVE FEEDBACK;
CUTTING EDGE;
RESPONSES;
RECEPTOR;
INNATE;
D O I:
10.1016/j.virol.2009.05.013
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Type I interferons (IFNs) are innate cytokines with potent antiviral and immunoregulatory activities. It remains unclear how human cytomegalovirus (HCMV) can establish persistence in the face of these strongly antagonistic cytokines. In this study, we confirm that IFN-alpha efficiently suppresses the penetration of HCMV into susceptible cells, including monocytes, the major cell population in peripheral blood that is highly susceptible to HCMV infection. We further demonstrate that the HCMV-derived interleukin 10 (IL-10) homolog functions similar to cellular IL-10 and broadly inhibits TLR-induced transcriptional activation of IFN-alpha/beta genes in plasmacytoid dendritic cells (PDCs), a major type I IFN-producer in vivo that is highly resistant to HCMV infection in vitro. These results suggest that HCMV subverts innate immunity by suppressing type I IFN production of PDCs during primary viral infection via its IL-10 homolog. (C) 2009 Elsevier Inc. All rights reserved.
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页码:330 / 337
页数:8
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