Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

被引：4
|
作者：
Cen, Ling-Ping [1 ,2 ]
Ng, Tsz [1 ,2 ,3 ,4 ]
Chu, Wai [4 ]
Pang, Chi [1 ,2 ,4 ]
机构：
[1] Shantou Univ, Joint Shantou Int Eye Ctr, Shantou, Guangdong, Peoples R China
[2] Chinese Univ Hong Kong, Shantou, Guangdong, Peoples R China
[3] Shantou Univ, Coll Med, Shantou, Guangdong, Peoples R China
[4] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2022年 / 17卷 / 12期
基金：
中国国家自然科学基金;
关键词：
agonists; antagonists; growth hormone-releasing hormone receptor; macrophages; neuroprotection; ocular inflammation; optic nerve injury; retinal ganglion cells; uveitis; MILD COGNITIVE IMPAIRMENT; GH DEFICIENCY; FACTOR GRF; ANALOGS; ANTAGONISTS; EXPRESSION; AGONISTS; CELLS; ACTIVATION; SECRETION;
D O I：
10.4103/1673-5374.336135
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs, some with systemic complications. Such effects are also found in ocular inflammatory and neurologic injury studies. In experimental models of mice and rats, both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental conditions. This review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.
引用
收藏
页码：2643 / 2648
页数：6
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