Human beta-defensin-3: A promising antimicrobial peptide

被引:36
作者
Batoni, G. [1 ]
Maisetta, G. [1 ]
Esin, S. [1 ]
Campa, M. [1 ]
机构
[1] Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, I-56127 Pisa, Italy
关键词
antimicrobial peptides; human beta-defensin-3; drug resistant microorganisms; new antimicrobial drugs; peptide structure;
D O I
10.2174/138955706778560193
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The field of naturally occurring antimicrobial peptides is a research area rapidly expanding due to the high potential of such molecules as new antimicrobial drugs. In this regard, the human beta-defensin-3 is particularly attractive because of its strong antibacterial activity, relative salt-insensitiveness and low toxicity for host cells.
引用
收藏
页码:1063 / 1073
页数:11
相关论文
共 93 条
  • [1] Aarbiou J, 2002, J LEUKOCYTE BIOL, V72, P167
  • [2] Burkholderia cepacia is resistant to the antimicrobial activity of airway epithelial cells
    Baird, RM
    Brown, H
    Smith, AW
    Watson, ML
    [J]. IMMUNOPHARMACOLOGY, 1999, 44 (03): : 267 - 272
  • [3] Befus AD, 1999, J IMMUNOL, V163, P947
  • [4] HBD-1 - A NOVEL BETA-DEFENSIN FROM HUMAN PLASMA
    BENSCH, KW
    RAIDA, M
    MAGERT, HJ
    SCHULZKNAPPE, P
    FORSSMANN, WG
    [J]. FEBS LETTERS, 1995, 368 (02) : 331 - 335
  • [5] Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids
    Bianchi, M
    Meng, C
    Ivashkiv, LB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (17) : 9573 - 9578
  • [6] Expression of β-defensins in gingival health and in periodontal disease
    Bissell, J
    Joly, S
    Johnson, GK
    Organ, CC
    Dawson, D
    McCray, PB
    Guthmiller, JM
    [J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2004, 33 (05) : 278 - 285
  • [7] A study of host defence peptide β-defensin 3 in primates
    Boniotto, M
    Antcheva, N
    Zelezetsky, I
    Tossi, A
    Palumbo, V
    Falzacappa, MVV
    Sgubin, S
    Braida, L
    Amoroso, A
    Crovella, S
    [J]. BIOCHEMICAL JOURNAL, 2003, 374 : 707 - 714
  • [8] Treponema denticola is resistant to human β-defensins
    Brissette, CA
    Lukehart, SA
    [J]. INFECTION AND IMMUNITY, 2002, 70 (07) : 3982 - 3984
  • [9] Chaly YV, 2000, EUR CYTOKINE NETW, V11, P257
  • [10] CHEN H, 2005, PEPTIDES 1011