Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials

被引：19
|
作者：
Roshanov, Pavel S. [1 ]
Dennis, Brittany B. [2 ]
机构：
[1] Univ Western Ontario, Schulich Sch Med & Dent, London, ON N6G 2M1, Canada
[2] St Josephs Healthcare Hamilton, Peter Boris Ctr Addict Res, Hamilton, ON L8N 4A6, Canada
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2015年 / 110卷 / 03期
关键词：
Acute pancreatitis; Gliptins; Incretins; DDP4; inhibitors; Safety; CARDIOVASCULAR OUTCOMES;
D O I：
10.1016/j.diabres.2015.10.014
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82). (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：E13 / E17
页数：5
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