Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials

被引：19

作者：

Roshanov, Pavel S. ^{[1
]}

Dennis, Brittany B. ^{[2
]}

机构：

[1] Univ Western Ontario, Schulich Sch Med & Dent, London, ON N6G 2M1, Canada

[2] St Josephs Healthcare Hamilton, Peter Boris Ctr Addict Res, Hamilton, ON L8N 4A6, Canada

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2015年 / 110卷 / 03期

关键词：

Acute pancreatitis; Gliptins; Incretins; DDP4; inhibitors; Safety; CARDIOVASCULAR OUTCOMES;

D O I：

10.1016/j.diabres.2015.10.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82). (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E13 / E17

页数：5

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