Solid-phase access to polyhydroxypyrrolizidines by 1,3-dipolar cycloaddition of (S)-3-alkoxypyrroline N-oxide to maleate and crotonate derivatives

被引：21

作者：

Pisaneschi, F ^{[1
]}

Della Monica, C ^{[1
]}

Cordero, FM ^{[1
]}

Brandi, A ^{[1
]}

机构：

[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, Polo Sci, I-50019 Sesto Fiorentino, FI, Italy

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 33期

关键词：

solid-phase synthesis; 1,3-dipolar cycloaddition; nitrone; pyrrolizidines;

D O I：

10.1016/S0040-4039(02)01208-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,7-Dihydroxyhexahydropyrrolizine-1-carboxylic acid derivatives have been prepared in solid-phase by intermolecular 1,3-dipolar cycloaddition between an immobilised malcate or 4-hydroxycrotonate and an enantiopure 3-alkoxypyrroline N-oxide. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5711 / 5714

页数：4

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