Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects

被引：33
作者：
Cheng, Tianze [1 ]
Wallace, Dominique Marie [2 ]
Ponteri, Benjamin [1 ]
Tuli, Mahir [3 ]
机构：
[1] Pitzer Coll, Claremont, CA 91711 USA
[2] Portland State Univ, Portland, OR 97207 USA
[3] Univ British Columbia, Vancouver, BC, Canada
来源：
NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2018年 / 14卷
关键词：
benzodiazepines; subtype; tolerance; dependence; anxiolytic; GABA(A) receptor; CLATHRIN-COATED VESICLES; VENTRAL TEGMENTAL AREA; ANTICONVULSANT TOLERANCE; ALPHA-5; SUBUNIT; UP-REGULATION; ANXIOLYTIC PROPERTIES; DOPAMINE NEURONS; PANIC DISORDER; DOUBLE-BLIND; DIAZEPAM;
D O I：
10.2147/NDT.S164307
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over the past two decades, advances in the neuropharmacological understanding of gamma aminobutyric acid (GABA) A receptors revealed distinct contributions from each subtype and produced effects. Recent findings have highlighted the importance of alpha(1) containing GABAA receptors in the mechanisms of addiction and tolerance in benzodiazepine treatments. This has shown promise in the development of tranquilizers with minimal side effects such as cognitive impairment, dependence, and tolerance. A valium-like drug without its side effects, as repeatedly demonstrated in animals, is achievable.
引用
收藏
页码：1351 / 1361
页数：11
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