A Green and Efficient Synthesis of Substituted 2-(4-(2-Oxo-2H-chromen-3-yl)thiazol-2-yl)-3-phenylacrylonitriles Under Environmentally Benign Conditions

被引：0

作者：

Kavitha, Kotthireddy ^{[1
]}

Srikrishna, Devulapally ^{[1
]}

Dubey, Pramod Kumar ^{[1
]}

Aparna, Pasula ^{[1
]}

机构：

[1] Jawaharlal Nehru Technol Univ Hyderabad, Coll Engn, Dept Chem, Hyderabad 500085, Telangana, India

来源：

LETTERS IN ORGANIC CHEMISTRY | 2019年 / 16卷 / 08期

关键词：

Triphenylphosphine; PEG-600; tetrabutylammonium tribromide; environmentally benign; green synthesis; aldehyde; COUMARIN DERIVATIVES; BIOLOGICAL-ACTIVITY; FLUORESCENT-PROBES; THIAZOLES; DESIGN;

D O I：

10.2174/1570178616666181224112851

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient method for the condensation of various aldehydes with 2-(4-(2-oxo-2H-chromen-3-yl) thiazol-2-yl) acetonitrile has been demonstrated via triphenylphosphine-catalyzed Knoevenagel condensation in good to excellent yields. The effect of solvent on this reaction was studied. In addition, a tandem method for the synthesis of 2-(4-(2-oxo-2H-chromen-3-yl) thiazol-2-yl) acetonitrile has been outlined using tetrabutylammonium tribromide as an efficient, green and eco-friendly reagent. Subsequently, the latter was reacted with various aromatic aldehydes in the presence of PEG-600 as reaction media to afford the title compounds. These reactions have widened the scope and applicability of the use of tetrabutylammonium tribromide, triphenylphosphine in organic synthesis. All these synthesized compounds were characterized by IR, H-1-NMR, Mass and C-13-NMR spectral data.

引用

页码：637 / 642

页数：6

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