Synthesis and antiangiogenic activity of thioacetal artemisinin derivatives

被引：50
|
作者：
Oh, S
Jeong, IH
Ahn, CM
Shin, WS
Lee, S [1 ]
机构：
[1] Kwandong Univ, Coll Med, Dept Basic Sci, Kangnung 210701, South Korea
[2] Yonsei Univ, Dept Chem, Wonju 220710, South Korea
[3] Yonsei Univ, Wonju Coll Med, Dept Basic Sci, Wonju 220710, South Korea
[4] Kwandong Univ, Coll Med, Dept Microbiol, Kangnung 210701, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 14期
关键词：
angiogenesis; antiangiogenesis; artemisinin; thioacetal artemisinin;
D O I：
10.1016/j.bmc.2004.05.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Various thioacetal artemisinin derivatives can inhibit the angiogenesis and might be angiogenesis inhibitors. In particular, 10alpha-phenylthiodihydroartemisinins (5), 10beta-benzenesulfonyl-9-epi-dihydroartemisinin (14) and 10alpha-mercaptodihydroartemisinin (13) exhibit strong growth inhibition activity against HUVEC proliferation. Compound 11 have a good inhibitiory activity upon HUVEC tube formation, and 5 and 11 show a strong inhibitory effect on angiogenesis using CAM assay at 5 mug/egg by 90%. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3783 / 3790
页数：8
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