Chiral ruthenium(ii) complex as potent radiosensitizer of 125I through DNA-damage-mediated apoptosis

被引：6

作者：

Bai, Mingjun ^{[1
]}

Zeng, Zhaolin ^{[1
]}

Li, Li ^{[2
]}

Wu, Qiong ^{[2
]}

Zhang, Yanyang ^{[1
]}

Pan, Tao ^{[1
]}

Mu, Luwen ^{[1
]}

Zhu, Duo ^{[1
]}

Guan, Shouhai ^{[1
]}

Xie, Qiang ^{[1
]}

Mei, Wenjie ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Vasc Intervent Radiol, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2018年 / 8卷 / 37期

关键词：

G-QUADRUPLEX DNA; PERMANENT IMPLANTATION; SALVAGE THERAPY; MELANOMA-CELLS; PROLIFERATION; RADIOTHERAPY; CARCINOMA; BINDING; AKT; P53;

D O I：

10.1039/c8ra03383h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chiral ruthenium(ii) complex, -[Ru(bpy)(2)(o-tFMPIP)] (ClO4)(2) (o-tFMPIP = 2-trifluoromethylphenyl) imidazo [4,5-f][1,10]phenanthroline, was prepared and evaluated for its enhancement of the radiosensitivity of I-125 seeds. The synthetic Ru(ii) complex, LR042, effectively enhanced growth inhibition against HepG2 human hepatocellular liver carcinoma cells induced by I-125 seeds and consequently effectively promoted the apoptosis of tumor cells with increasing level of cleave-caspase-3. Furthermore, the results of immunofluorescence indicated that LR042 enhanced the phosphorylation of H2AX by I-125 seeds vigorously in response to damaged DNA. LR042 improved DNA damage induced by I-125 seeds, which resulted in apoptosis through the activation of the p53/AKT signal. In conclusion, synthetic LR042 can be further developed as a potential radiosensitizer of I-125 seed radiotherapy for cancer therapy.

引用

页码：20612 / 20618

页数：7

共 41 条

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