Outcomes in Patients with pT1-T2, pN0-N1 Breast Cancer After Conservative Surgery and Whole-breast Radiotherapy

被引：3
作者：
Trignani, Marianna [1 ]
Di Carlo, Clelia [1 ]
Cefalogli, Carmen [1 ]
Nuzzo, Marianna [1 ]
Ursini, Lucia Anna [1 ]
Caravatta, Luciana [1 ]
Perrotti, Francesca [1 ]
Di Nicola, Marta [2 ]
Pamio, Ambra [3 ]
Genovesi, Domenico [1 ]
机构：
[1] GD Annunzio Univ Chieti, SS Annunziata Hosp, Dept Med & Sci Aging, Dept Radiat Oncol, Chieti, Italy
[2] GD Annunzio Univ Chieti, Dept Med & Sci Aging, Dept Med Oral & Biotechnol Sci, Lab Biostat, Chieti, Italy
[3] GD Annunzio Univ Chieti, Dept Med & Sci Aging, Div Hygene Epidemiol & Publ Hlth, Chieti, Italy
来源：
IN VIVO | 2017年 / 31卷 / 01期
关键词：
Breast cancer; pT1-T2; pN0-N1; adjuvant radiotherapy; conservative surgery; AXILLARY LYMPH-NODES; POSTMASTECTOMY LOCOREGIONAL RECURRENCE; NODAL IRRADIATION; CONSERVING SURGERY; SURVIVAL; LUMPECTOMY; FAILURE; T1;
D O I：
10.21873/invivo.11039
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To evaluate locoregional recurrence, overall survival, disease-free survival and prognostic influence of the number of positive lymph nodes and other variables in breast cancer treatment. Patients and Methods: A total of 377 patients with pT1-T2, pN0-N1 invasive breast carcinoma treated from 2005 to 2013 were retrospectively evaluated. Patients underwent conservative surgery followed by whole-breast radiotherapy. Clavicular region irradiation was not performed. Results: With a median follow-up of 4 years, locoregional recurrence rate was 3.4% (nodal recurrence=1.06%). Expression of progesterone receptors was significantly associated with better disease-free survival, tumor size (T>2 cm) with poorer disease-free survival, locoregional recurrence and poorer overall survival; the presence of three nodal metastases was related to significantly poorer overall survival (p=0.024). Conclusion: Whole-breast adjuvant radiotherapy without nodal irradiation after breast-conserving surgery led to low rate of locoregional recurrence and high rates of overall survival and disease-free survival in patients with pT1-T2 pN0-N1 breast cancer.
引用
收藏
页码：151 / 158
页数：8
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