A New Cycloartane Glucoside from Rhizophora stylosa

被引：1

作者：

Phan Thi Thanh Huong ^{[1
]}

Chau Ngoc Diep ^{[1
]}

Nguyen Van Thanh ^{[1
]}

Vu Anh Tu ^{[1
]}

Tran Hong Hanh ^{[1
]}

Nguyen The Cuong ^{[2
]}

Nguyen Phuong Thao ^{[1
]}

Nguyen Xuan Cuong ^{[1
]}

Do Thi Thao ^{[3
]}

Tran Huy Thai ^{[2
]}

Nguyen Hoai Nam ^{[1
]}

Ninh Khac Ban ^{[1
]}

Phan Van Kiem ^{[1
]}

Chau Van Minh ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem IMBC, Hanoi, Vietnam

[2] VAST, Inst Ecol & Biol Resources, Hanoi, Vietnam

[3] VAST, Inst Biotechnol, Hanoi, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 09期

关键词：

Rhizophora stylosa; Rhizophoraceae; Cycloartane; Rhizostyloside; Cytotoxic activity; Caspase-3/7; GLYCOSIDES; CONSTITUENTS; DERIVATIVES; MULTIFLORA; ROOTS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (H-1 and C-13 NMR, HSQC, HMBC, H-1-H-1 COSY, NOESY) and HR-BSI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.

引用

页码：1255 / 1257

页数：3

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