Recent advances in the synthesis of Quinazoline analogues as Anti-TB agents

被引：41

作者：

Dutta, Apurba ^{[1
]}

Sarma, Diganta ^{[1
]}

机构：

[1] Dibrugarh Univ, Dept Chem, Dibrugarh 786004, Assam, India

来源：

TUBERCULOSIS | 2020年 / 124卷

关键词：

Mycobacterium tuberculosis; Anti-tubercular drugs; Heterocyclic chemistry; Quinazoline analogues; Structure-activity relationship; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; ADHATODA-VASICA; DERIVATIVES; CATALYST; DESIGN; 1,2-DIHYDROQUINAZOLIN-4(3H)-ONES; ALDEHYDES; SAMARIUM; WATER;

D O I：

10.1016/j.tube.2020.101986

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Quinazoline analogues are one of the important nitrogen containing heterocycles that have significant bioactivity as well as found in a plethora of natural products. Tuberculosis is one of the serious universal health threats caused by Mycobacterium tuberculosis (MTB) and primarily affects the lungs. Due to their significant bioactivity and natural occurrences of quinazolines, researchers are trying to synthesize new quinazoline analogues which may have significant potency against tuberculosis. This particular review summarizes recent development of different types of quinazoline bearing analogues as anti-tubercular (anti-TB) agents and their synthesis with structure-activity relationship.

引用

页数：19

共 64 条

[21] Design, synthesis and biological evaluation of novel 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives as a potential DprE1 inhibitors [J].