Analysis of outcomes following surgical treatment of thymolipomatous myasthenia gravis: comparison with thymomatous and non-thymomatous myasthenia gravis

被引:16
|
作者
Huang, Chien-Sheng [1 ,2 ]
Li, Wing-Yin [3 ]
Lee, Pei-Chen [4 ]
Kao, Ko-Pei [5 ]
Chou, Teh-Ying [2 ,3 ]
Wu, Mei-Han [6 ]
Hsu, Han-Shui [1 ,7 ]
Wu, Yu-Chung [1 ]
Hsu, Wen-Hu [1 ]
Huang, Biing-Shiun [1 ,8 ,9 ]
机构
[1] Taipei Vet Gen Hosp, Div Thorac Surg, Dept Surg, Taipei, Taiwan
[2] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan
[3] Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan
[4] Natl Taipei Univ Nursing & Hlth Sci, Dept Hlth Care Management, Coll Healthcare Adm & Management, Taipei, Taiwan
[5] Taipei Vet Gen Hosp, Dept Neurol, Taipei, Taiwan
[6] Taipei Vet Gen Hosp, Dept Radiol, Taipei, Taiwan
[7] Natl Yang Ming Univ, Inst Emergency & Crit Care Med, Sch Med, Taipei 112, Taiwan
[8] Taipei Med Univ, Taipei, Taiwan
[9] Taipei Municipal Gan Dau Hosp, Taipei, Taiwan
关键词
Thymectomy; Thymolipoma; Myasthenia gravis; Anterior mediastinal tumour; CARBOHYDRATE ANTIGEN 19-9; THYMECTOMY; ASSOCIATION;
D O I
10.1093/icvts/ivt531
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although significant improvement in myasthenic symptoms has been reported following the removal of thymolipomas, information on surgical outcomes among patients with thymolipomatous myasthenia gravis (MG) is limited. This was a retrospective review of patients who underwent extended thymectomy for treatment of MG. From 1995 to 2010, 267 patients with MG underwent extended thymectomy, including 104 with thymomatous MG, 151 with non-thymomatous MG and 12 (4.4%) with thymolipoma. The mean duration of myasthenic symptoms before surgery was greatest in the thymolipomatous group (P < 0.001). The lowest mean age (36.1 years old, P < 0.001) and the lowest preoperative serum anti-acetylcholine receptor antibody titre (P = 0.015) occurred in the non-thymomatous group. More thymic and adipose tissue was removed from the thymolipomatous group compared with the non-thymomatous group (P < 0.001). Regarding surgical outcomes, the rate of stable remission was higher in the non-thymomatous (42.3%) and thymolipomatous (41.7%) groups compared with the thymomatous group (28.8%, P = 0.029). No instances of postoperative exacerbation of MG or tumour recurrence were noted during the postoperative follow-up of patients treated for thymolipoma. Our results suggest that patients with myasthenia thymolipomatous have surgical outcomes similar to those of patients with non-thymomatous MG and have a mean age at the time of surgery similar to that of patients with thymomatous MG.
引用
收藏
页码:475 / 481
页数:7
相关论文
共 50 条
  • [21] Effectiveness of thymectomy in non-thymomatous myasthenia gravis: a systematic review
    Luo, Yan
    Pan, Deng-ji
    Chen, Fei-fei
    Zhu, Ming-hui
    Wang, Jing
    Zhang, Min
    JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2014, 34 (06) : 942 - 949
  • [22] Effectiveness of thymectomy in non-thymomatous myasthenia gravis: a systematic review
    Yan Luo
    Deng-ji Pan
    Fei-fei Chen
    Ming-hui Zhu
    Jing Wang
    Min Zhang
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2014, 34 : 942 - 949
  • [23] Subxiphoid completion thymectomy for refractory non-thymomatous myasthenia gravis
    Ambrogi, Vincenzo
    Tacconi, Federico
    Sellitri, Francesco
    Tamburrini, Alessandro
    Perroni, Gianluca
    Carlea, Federica
    La Rocca, Eleonora
    Vanni, Gianluca
    Schillaci, Orazio
    Mineo, Tommaso Claudio
    JOURNAL OF THORACIC DISEASE, 2020, 12 (05) : 2388 - 2394
  • [24] Effect of thymectomy on late onset non-thymomatous myasthenia gravis
    Kawaguchi, N.
    Kuwabara, S.
    Nemoto, Y.
    Fukutake, T.
    Arimura, K.
    Osame, M.
    Hattori, T.
    8TH INTERNATIONAL CONGRESS OF NEUROIMMUNOLOGY, 2006, : 155 - 158
  • [25] Effect of thymectomy in elderly patients with non-thymomatous generalized myasthenia gravis
    Kim, Seung Woo
    Choi, Young-Chul
    Kim, Seung Min
    Shim, Hyo Sup
    Shin, Ha Young
    JOURNAL OF NEUROLOGY, 2019, 266 (04) : 960 - 968
  • [26] Differentiation and characterization of non-thymomatous ocular myasthenia gravis children with CT
    Cai, Youran
    Cheng, Zhongyuan
    Yang, Yuanting
    Xu, Baojun
    Feng, Qiwen
    Liu, Xu
    Chen, Jian
    Zhou, Qing
    ACTA NEUROLOGICA BELGICA, 2025, 125 (01) : 149 - 156
  • [27] Thymectomy for non-thymomatous myasthenia gravis: a propensity score matched study
    Carolina Barnett
    Hans D Katzberg
    Shaf Keshavjee
    Vera Bril
    Orphanet Journal of Rare Diseases, 9
  • [28] Effect of thymectomy in elderly patients with non-thymomatous generalized myasthenia gravis
    Seung Woo Kim
    Young-Chul Choi
    Seung Min Kim
    Hyo Sup Shim
    Ha Young Shin
    Journal of Neurology, 2019, 266 : 960 - 968
  • [29] Thymectomy for non-thymomatous myasthenia gravis: a propensity score matched study
    Barnett, Carolina
    Katzberg, Hans D.
    Keshavjee, Shaf
    Bril, Vera
    ORPHANET JOURNAL OF RARE DISEASES, 2014, 9 : 214
  • [30] EFFECT OF THYMECTOMY IN ELDERLY NON-THYMOMATOUS GENERALIZED MYASTHENIA GRAVIS PATIENTS
    Kim, S.
    Choi, Y.
    Kim, S.
    Shin, H.
    MUSCLE & NERVE, 2018, 58 : S111 - S111