Structural and Functional Coordination of DNA and Histone Methylation

被引：81

作者：

Cheng, Xiaodong ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2014年 / 6卷 / 08期

基金：

美国国家卫生研究院;

关键词：

PROTEIN-ARGININE METHYLTRANSFERASE; MIXED LINEAGE LEUKEMIA; DE-NOVO METHYLATION; MAJOR SATELLITE REPEATS; ACUTE MYELOID-LEUKEMIA; RNA-POLYMERASE-II; MAMMALIAN DNA; PWWP DOMAIN; TRANSCRIPTIONAL ACTIVATION; PRODUCT SPECIFICITY;

D O I：

10.1101/cshperspect.a018747

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of the most fundamental questions in the control of gene expression in mammals is how epigenetic methylation patterns of DNA and histones are established, erased, and recognized. This central process in controlling gene expression includes coordinated covalent modifications of DNA and its associated histones. This article focuses on structural aspects of enzymatic activities of histone (arginine and lysine) methylation and demethylation and functional links between the methylation status of the DNA and histones. An interconnected network of methyltransferases, demethylases, and accessory proteins is responsible for changing or maintaining the modification status of specific regions of chromatin.

引用

页数：23

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