The URNA genes of herpesvirus saimiri (strain C488) are dispensable for transformation of human T cells in vitro

被引：30

作者：

Ensser, A ^{[1
]}

Pfinder, A ^{[1
]}

Müller-Fleckenstein, I ^{[1
]}

Fleckenstein, B ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Klin & Mol Virol, D-91054 Erlangen, Germany

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 12期

关键词：

D O I：

10.1128/JVI.73.12.10551-10555.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The herpesvirus saimiri strain C488 genome contains five genes for small nuclear RNAs, termed herpesvirus saimiri URNAs (or HSURs). Using a cosmid-based approach, all HSURs were precisely deleted from the genome. The mutant virus replicated at levels that were similar to those of wild-type viruses in OMK cells. Although the HSURs are expressed in wild-type virus-transformed human T-cell lines, the deletion does not affect viral transformation in cell culture.

引用

页码：10551 / 10555

页数：5

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