Myelodysplastic features in visceral leishmaniasis

被引:20
作者
Yarali, N [1 ]
Fisgin, T [1 ]
Duru, F [1 ]
Kara, A [1 ]
机构
[1] Dr Sami Ulus Childrens Hosp, Dept Pediat Hematol, Ankara, Turkey
关键词
visceral leishmaniasis; myelodysplasia;
D O I
10.1002/ajh.10200
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have detected trilineage myelodysplasia in two children recently diagnosed to have visceral leishmaniasis (V.L.), which led us to investigate retrospectively available peripheral blood and bone marrow aspirate smears of 5 children previously diagnosed as V.L. We saw that they also had trilineage myelodysplasia. We postulate that elevated levels of tumor necrosis factor-alpha (TNFalpha) may cause trilineage myelodysplasia in the patients with V.L. This nonclonal myelodysplasia may be responsible for pancytopenia along with hypersplenism, hemolysis and reticuloendothelial hyperplasia causing abnormal retention of iron in V.L. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:191 / 195
页数:5
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