Site-specific serine incorporation by Lif and Epr into positions 3 and 5 of the staphylococcal peptidoglycan interpeptide bridge

被引:43
作者
Ehlert, K
Tschierske, M
Mori, C
Schröder, W
Berger-Bächi, B
机构
[1] Univ Zurich, Inst Med Microbiol, CH-8028 Zurich, Switzerland
[2] Bayer AG, PH Res Antiinfect 1, D-42096 Wuppertal, Germany
关键词
D O I
10.1128/JB.182.9.2635-2638.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The FemAB-like factors Lif and Epr confer resistance to glycylglycine endopeptidases lysostaphin and Ale-1, respectively, by incorporating serine residues into the staphylococcal peptidoglycan interpeptide bridges specifically at positions 3 and 5. This required the presence of FemA and/or FemB, in contrast to earlier postulations.
引用
收藏
页码:2635 / 2638
页数:4
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