New Consensus Definitions for Sepsis and Septic Shock: Implications for Treatment Strategies and Drug Development?

被引：6
作者：
Berry, Michael [1 ]
Patel, Brijesh V. [2 ,3 ]
Brett, Stephen J. [3 ,4 ]
机构：
[1] Imperial Sch Anaesthesia, London, England
[2] Royal Brompton & Harefield NHS Fdn, Adult ICU, London, England
[3] Imperial Coll London, Dept Surg & Canc, Sect Anaesthesia Pain Med & Intens Care, London, England
[4] Imperial Coll Healthcare NHS Trust, Ctr Perioperat Med & Crit Care Res, London, England
来源：
DRUGS | 2017年 / 77卷 / 04期
关键词：
GOAL-DIRECTED RESUSCITATION; NOREPINEPHRINE; THERAPY; VASOPRESSIN; BIOMARKERS; GUIDELINES; MANAGEMENT; MORTALITY; CRITERIA; FAILURE;
D O I：
10.1007/s40265-017-0698-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Sepsis continues to escape a precise diagnostic definition. The most recent consensus definition, termed Sepsis-3, highlights the importance of the maladaptive and potentially life-threatening host response to infection. After briefly reviewing the history and epidemiology of sepsis, we go on to describe some of the challenges encountered when classifying such a heterogenous disease state. In the context of these new definitions for sepsis and septic shock, we explore current and potentially novel therapies, and conclude by mentioning some of the controversies of this most recent framework.
引用
收藏
页码：353 / 361
页数：9
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