Determination of Exemestane in bulk and pharmaceutical dosage form by HPTLC

被引：5

作者：

Mane, Maya B. ^{[1
]}

Sangshetti, Jaiprakash N. ^{[1
]}

Wavhal, Parmeshwar J. ^{[1
]}

Wakte, Pravin S. ^{[1
]}

Shinde, Devanand B. ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2014年 / 7卷 / 04期

关键词：

HPTLC; Exemestane; Bulk; Tablet formulation; IRREVERSIBLE AROMATASE INHIBITOR; BREAST-CANCER PATIENTS; PHASE-I; FCE-24304; ENDOCRINE; PLASMA;

D O I：

10.1016/j.arabjc.2010.11.009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An HPTLC method for analysis of Exemestane in bulk and pharmaceutical formulation has been established and validated. The analyte was separated on aluminium plates precoated with silica gel 60 F-254. The mobile phase was chloroform:methanol 9.2:0.8 (v/v). Quantification was done by densitometric scanning at 247 am. Response was a linear function of Exemestane concentration in the range of 100-500 mu g mL(-1). The limit of detection and quantification for Exemestane were 5.8 and 17.58 mu g mL(-1), respectively. Average recovery of Exemestane was 100.1, which shows that the method was free from interference from excipients present in the formulation. The established method enabled accurate, precise, and rapid analysis of Exemestane in bulk as well as pharmaceutical formulation. (C) 2010 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：504 / 508

页数：5

共 6 条

[1] DETERMINATION OF PLASMA-LEVELS OF EXEMESTANE (FCE-24304), A NEW IRREVERSIBLE AROMATASE INHIBITOR, USING THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY [J].