Genetic Thrombophilias and Intrauterine Growth Restriction A Meta-analysis

被引:38
作者
Facco, Francesca [1 ]
You, Whitney [1 ]
Grobman, William [1 ]
机构
[1] Northwestern Univ, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Chicago, IL 60611 USA
关键词
FACTOR-V-LEIDEN; METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISMS; LOW-BIRTH-WEIGHT; FETAL-GROWTH; PREGNANCY COMPLICATIONS; PUBLICATION BIAS; INHERITED THROMBOPHILIAS; HORDALAND HOMOCYSTEINE; PROTHROMBIN GENE; CHILDHOOD GROWTH;
D O I
10.1097/AOG.0b013e3181a6e96a
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: To estimate the relationship between inherited thrombophilias and intrauterine growth restriction (IUGR) using meta-analytic techniques. METHODS: A literature review identified case-control and cohort studies evaluating the relationship between IUGR and the following thrombophilias: homozygous or heterozygous factor V Leiden or prothrombin (PT) G20210A mutations and homozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation. Using mixed effects and random-effects models, the association between thrombophilias and IUGR was explored. Publication bias was assessed with funnel plots and corrected for with Duval and Tweedie's trim-and-fill method. RESULTS: The following number of related studies were found: studies evaluating relationships between factor V Leiden mutation and IUGR, 12 case-control and four cohort; between PT mutation and IUGR, 11 case-control and 0 cohort; and between MTHFR C677T homozygosity and IUGR, 10 case-control and two cohort. The overall summary odds ratio (OR) for the association between factor V Leiden and IUGR was significant (OR 1.23, 95% confidence interval [CI] 1.04-1.44); however, this was mainly driven by the positive association seen in the case-control studies (OR 1.91, 95% Cl 1.17-3.12). The association between PT and IUGR was only explored in case-control studies yielding a summary OR that was not significant (OR 1.52, 95% Cl 0.98-2.35). The overall summary OR for the association between MTHFR and IUGR was not significant (OR 1.01, 95% Cl 0.88-1.17), but was significant for the case-control studies alone (OR 1.35, 95% Cl 1.04-1.75). For both factor V Leiden and MTHFR mutations, a funnel-plot analysis of the case-control studies suggests publication bias. When the trim- and fill-method was used to correct for the publication bias, these summary estimates were no longer significant. CONCLUSION: The association between inherited thrombophilias and IUGR can only be discerned in case-control studies and seems to be largely because of publication bias. (Obstet Gynecol 2009;113:1206-16)
引用
收藏
页码:1206 / 1216
页数:11
相关论文
共 49 条
[1]  
Agorastos T, 2002, J Matern Fetal Neonatal Med, V12, P267, DOI 10.1080/713605679
[2]  
*AM COLL OBST GYN, 2008, ACOG PRACT B, V12
[3]  
BARKER DJP, 1989, LANCET, V2, P577
[4]   Fetal origins of cardiovascular disease [J].
Barker, DJP .
ANNALS OF MEDICINE, 1999, 31 :3-6
[5]   The relationship of the factor v Leiden mutation and pregnancy outcomes for mother and fetus [J].
Dizon-Townson, D ;
Miller, C ;
Sibai, B ;
Spong, CY ;
Thom, E ;
Wendel, G ;
Wenstrom, K ;
Samuels, P ;
Cotroneo, MA ;
Moawad, A ;
Sorokin, Y ;
Meis, P ;
Miodovnik, M ;
O'Sullivan, M ;
Conway, D ;
Wapner, RJ ;
Gabbe, SG .
OBSTETRICS AND GYNECOLOGY, 2005, 106 (03) :517-524
[6]   ANTEPARTUM FETAL HEART-RATE TESTING .7. THE SIGNIFICANCE OF FETAL BRADYCARDIA [J].
DRUZIN, ML ;
GRATACOS, J ;
KEEGAN, KA ;
PAUL, RH .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1981, 139 (02) :194-198
[7]   Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis [J].
Dudding, T. ;
Heron, J. ;
Thakkinstian, A. ;
Nurk, E. ;
Golding, J. ;
Pembrey, M. ;
Ring, S. M. ;
Attia, J. ;
Scott, R. J. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (11) :1868-1875
[8]   Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis [J].
Duval, S ;
Tweedie, R .
BIOMETRICS, 2000, 56 (02) :455-463
[9]   Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth [J].
Engel, Stephanie M. ;
Olshan, Andrew F. ;
Siega-Riz, Anna Maria ;
Savitz, David A. ;
Chanock, Stephen J. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2006, 195 (05) :1231-1239
[10]  
Franchi F, 2004, HAEMATOLOGICA, V89, P444