Carbazole alkaloids from the peels of Clausena lansium

被引：28

作者：

Deng, Hui-Dong ^{[1
,2
]}

Mei, Wen-Li ^{[1
]}

Wang, Hui ^{[1
]}

Guo, Zhi-Kai ^{[1
]}

Dong, Wen-Hua ^{[1
]}

Wang, Hao ^{[1
]}

Li, Shao-Peng ^{[2
]}

Dai, Hao-Fu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

[2] Hainan Univ, Key Lab Protect & Dev Utilizat Trop Crop Germplas, Minist Educ, Coll Hort & Landscape Architecture, Haikou 570228, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 10期

关键词：

Clausena lansium; Rutaceae; carbazole alkaloids; alpha-glucosidase inhibitory activity; antibacterial activity; ANTIOXIDANT; COUMARINS; SEEDS;

D O I：

10.1080/10286020.2014.930442

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new carbazole alkaloid, claulansine K (1), together with six known carbazole alkaloids (2-7), was isolated from the peels of Clausena lansium (Lour.) Skeels. The new compound was elucidated using a combination of 1D and 2D NMR (HMQC, HMBC, COSY, and ROESY) techniques, and HR-EI-MS analyses. Compound 1 showed in vitro alpha-glucosidase inhibitory activity with the IC50 value of 0.11 mM. Compound 2 exhibited moderate antibacterial activity against Staphylococcus aureus with the diameter of inhibition zone of 14.2 mm.

引用

页码：1024 / 1028

页数：5

共 22 条

[1] Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: Anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects [J].