Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons

被引：272
作者：
Honma, Y
Araki, T
Gianino, S
Bruce, A
Heuckeroth, RO
Johnson, EM
Milbrandt, J
机构：
[1] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
来源：
NEURON | 2002年 / 35卷 / 02期
关键词：
D O I：
10.1016/S0896-6273(02)00774-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRalpha3 receptor complex. Characterization of ARTN- and GFRalpha3-deficient mice revealed similar abnormalities in the migration and axonal projection pattern of the entire sympathetic nervous system. This resulted in abnormal innervation of target tissues and consequent cell death due to deficiencies of target-derived neurotrophic support. ARTN is expressed along blood vessels and in cells nearby to sympathetic axonal projections. In the developing vasculature, ARTN is expressed in smooth muscle cells of the vessels, and it acts as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues. The chemoattractive properties of ARTN were confirmed by the demonstration that sympathetic neuroblasts migrate and project axons toward ARTN-soaked beads implanted into mouse embryos.
引用
收藏
页码：267 / 282
页数：16
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