General and programmable synthesis of hybrid liposome/metal nanoparticles

被引:58
作者
Lee, Jin-Ho [1 ,2 ]
Shin, Yonghee [1 ]
Lee, Wooju [3 ]
Whang, Keumrai [1 ]
Kim, Dongchoul [3 ]
Lee, Luke P. [2 ]
Choi, Jeong-Woo [1 ]
Kang, Taewook [1 ]
机构
[1] Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
[2] Univ Calif Berkeley, Biomol Nanotechnol Ctr, Berkeley Sensor & Actuator Ctr, Dept Bioengn, Berkeley, CA 94720 USA
[3] Sogang Univ, Dept Mech Engn, Seoul 121742, South Korea
来源
SCIENCE ADVANCES | 2016年 / 2卷 / 12期
基金
新加坡国家研究基金会;
关键词
GOLD NANOPARTICLES; IN-VIVO; PLATINUM NANOPARTICLES; SILVER NANOPARTICLES; PHOTOTHERMAL THERAPY; LIPID-MEMBRANE; CANCER-THERAPY; DRUG-DELIVERY; AU; STABILITY;
D O I
10.1126/sciadv.1601838
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hybrid liposome/metal nanoparticles are promising candidate materials for biomedical applications. However, the poor selectivity and low yield of the desired hybrid during synthesis pose a challenge. We designed a programmable liposome by selective encoding of a reducing agent, which allows self-crystallization of metal nanoparticles within the liposome to produce stable liposome/metal nanoparticles alone. We synthesized seven types of liposome/monometallic and more complex liposome/bimetallic hybrids. The resulting nanoparticles are tunable in size and metal composition, and their surface plasmon resonance bands are controllable in visible and near infrared. Owing to outer lipid bilayer, our liposome/Au nanoparticle shows better colloidal stability in biologically relevant solutions as well as higher endocytosis efficiency than gold nanoparticles without the liposome. We used this hybrid in intracellular imaging of living cells via surface-enhanced Raman spectroscopy, taking advantage of its improved physicochemical properties. We believe that our method greatly increases the utility of metal nanoparticles in in vivo applications.
引用
收藏
页数:9
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