Comparison of Clinical and Spectral Domain Optical Coherence Tomography Optic Disc Margin Anatomy

被引:119
作者
Strouthidis, Nicholas G. [1 ]
Yang, Hongli [1 ,2 ]
Reynaud, Juan F. [1 ]
Grimm, Jonathan L. [1 ]
Gardiner, Stuart K. [1 ]
Fortune, Brad [1 ]
Burgoyne, Claude F. [1 ]
机构
[1] Devers Eye Inst, Opt Nerve Head Res Lab, Portland, OR 97208 USA
[2] Tulane Univ, Dept Biomed Engn, New Orleans, LA 70118 USA
基金
美国国家卫生研究院;
关键词
NERVE HEAD; GLAUCOMA; ARCHITECTURE;
D O I
10.1167/iovs.09-3586
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE. To investigate spectral domain optical coherence tomography (SD-OCT)-detected optic disc margin anatomy in the monkey eye by colocalizing disc photographs to SD-OCT scans acquired from the same eyes. METHODS. The neural canal opening (NCO) was delineated within 40 digital radial sections generated from SD-OCT volumes acquired from 33 normal monkey eyes (15 degrees, 290 x 768 horizontal grid pattern). Each volume was colocalized to its disc photograph by matching the retinal vessels within each photograph to vessel outlines visible within en face SD-OCT images. Border tissue was delineated where it extended internally to the NCO. A clinician (masked to delineated points) marked the disc margin onto each photograph while viewing the relevant stereophotograph pair. Alignment of the clinician-ascribed disc margin to the NCO and border tissue delineation was assessed. The process was repeated in a single myopic human eye. RESULTS. In 23 eyes, the NCO aligned to the disc margin. In 10 eyes, externally oblique border tissue was detectable in the temporal disc. In these regions of the disc, the termination of border tissue was the disc margin. An exaggerated form of this phenotype was observed in the myopic human eye. In this case, temporal border tissue terminated at the anterior scleral canal opening, which was detected as the disc margin. CONCLUSIONS. The termination of Bruch's membrane, border tissue, and the anterior scleral canal opening may constitute the disc margin within the same eye, depending on the border tissue architecture; this anatomy is consistently visualized by SD-OCT. (Invest Ophthalmol Vis Sci.2009;50:4709-4718) DOI:10.1167/iovs.09-3586
引用
收藏
页码:4709 / 4718
页数:10
相关论文
共 19 条
[1]  
ANDERSON DR, 1969, ARCH OPHTHALMOL-CHIC, V82, P506
[2]  
[Anonymous], 2007, SPECTRALIS OPERATING
[3]   Three-dimensional reconstruction of normal and early glaucoma monkey optic nerve head connective tissues [J].
Burgoyne, CF ;
Downs, JC ;
Bellezza, AJ ;
Hart, RT .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (12) :4388-4399
[4]   Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: Neural canal and subarachnoid space architecture [J].
Downs, J. Crawford ;
Yang, Hongli ;
Girkin, Christopher ;
Sakata, Lisandro ;
Bellezza, Anthony ;
Thompson, Hilary ;
Burgoyne, Claude F. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (07) :3195-3208
[5]   State-of-the-art retinal optical coherence tomography [J].
Drexler, Wolfgang ;
Fujimoto, James G. .
PROGRESS IN RETINAL AND EYE RESEARCH, 2008, 27 (01) :45-88
[6]  
FANTES FE, 1989, OPHTHALMOLOGY, V96, P20
[7]   Relative course of retinal nerve fiber layer birefringence and thickness and retinal function changes after optic nerve transection [J].
Fortune, Brad ;
Cull, Grant A. ;
Burgoyne, Claude F. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2008, 49 (10) :4444-4452
[8]  
Hogan MJ, 1971, HISTOLOGY HUMAN EYE
[9]  
Jonas J.B., 1988, KLIN MONATSBL AUGENH, V192, P621
[10]  
Kotera Y, 2008, OPHTHAL SURG LAS IM, V39, pS62