Glycomic Analysis: An Array of Technologies

被引：120

作者：

Krishnamoorthy, Lakshmi ^{[1
]}

Mahal, Lara K. ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

来源：

ACS CHEMICAL BIOLOGY | 2009年 / 4卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Glycans; Glycoconjugates; Glycome; Lectins; Glycoproteomics; Microarrays; Mass spectrometry; Biomarkers; PROTEIN-CARBOHYDRATE INTERACTIONS; LECTIN AFFINITY-CHROMATOGRAPHY; MASS-SPECTROMETRIC ANALYSIS; GLCNAC-MODIFIED PROTEINS; N-LINKED GLYCOPROTEINS; SURFACE-PLASMON RESONANCE; PANCREATIC-CANCER SERUM; HEPATOCELLULAR-CARCINOMA; MICROARRAY APPROACH; O-GLYCOSYLATION;

D O I：

10.1021/cb900103n

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbohydrates encode biological information necessary for cellular function. The structural diversity and complexity of these sugar residues have necessitated the creation of novel methodologies for their study. This review highlights recent technological advancements that are starting to unravel the intricate web of carbohydrate biology. New methods for the analysis of both glycoconjugates and glycan structures are discussed. With the use of these innovative tools, the field of glycobiology is poised to take center-stage in the postgenomic era of modern biology and medicine.

引用

页码：715 / 732

页数：18

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