The influence of 17β-oestradiol on corticotrophin-releasing hormone induced suppression of luteinising hormone pulses and the role of CRH in hypoglycaemic stress-induced suppression of pulsatile LH secretion in the female rat

被引：47

作者：

Cates, PS ^{[1
]}

Li, XF ^{[1
]}

O'Byrne, KT ^{[1
]}

机构：

[1] Kings Coll London, GKT Sch Biomed Sci, Ctr Reprod Endocrinol & Diabet, London SE1 1UL, England

来源：

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | 2004年 / 7卷 / 02期

基金：

英国惠康基金;

关键词：

CRH; CRH antagonist; hypoglycaemia; LH pulses; oestradiol; stress;

D O I：

10.1080/1025389042000218988

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Corticotrophin-releasing hormone (CRH) released during stress has been implicated in the disruption of the reproductive neuroendocrine axis, and 17beta-oestradiol (E2) has been shown to enhance stress-induced suppression of pulsatile gonadotrophin-releasing hormone (GnRH) and luteinising hormone (LH) release. The aims of the present study were to examine the role of CRH in hypoglycaemic stress-induced suppression of LH pulses, and to investigate the influence of E, on the inhibitory effect of CRH on pulsatile LH secretion in the female rat. Suppression of LH pulses by insulin-induced hypoglycaemic (IIH) stress was completely prevented by intracerebroventricular (icv) administration of a CRH antagonist. Central administration of CRH (5 mug) resulted in an interruption of LH pulses in E2 treated animals, but had little or no effect in the absence of this gonadal steroid. These results provide evidence of a pivotal role for CRH in mediating the suppressive effect of IIH stress on pulsatile LH secretion in the female rat, and highlight a sensitising role for E-2 in CRH-induced suppression of LH pulses.

引用

页码：113 / 118

页数：6

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