Transient therapy-related myelodysplastic syndrome associated with monosomy 7 and 11q23 translocation

被引:21
作者
Laver, JH [1 ]
Yusuf, U [1 ]
Cantu, ES [1 ]
Barredo, JC [1 ]
Holt, LB [1 ]
Abboud, MR [1 ]
机构
[1] MED UNIV S CAROLINA,DEPT LAB MED,CHARLESTON,SC 29425
关键词
AML; MDS; monosomy; 7; 11q23; translocation;
D O I
10.1038/sj.leu.2400576
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Secondary acute myelocytic leukemia (AML) and myelodysplastic syndromes (MDS) are known to develop in patients previously treated with different chemotherapeutic regimens. Nonrandom chromosomal abnormalities have been demonstrated in these therapy-related myeloid disorders which often evolve into refractory AML. The prognosis of these patients with conventional chemotherapy has been dismal and only allogeneic bone marrow transplantation offers a potential cure. We describe two patients who developed MDS after chemo/ radiotherapy and had a spontaneous recovery. One patient was treated with MOPP-ABVD hybrid therapy for Hodgkin's disease, developed pancytopenia, marrow hypoplasia and dyserythropoiesis associated with monosomy 7. The other was treated with a combination of chemotherapy including VP-16 for Ewing's sarcoma, developed thrombocytopenia, marrow hypoplasia and dyserythropoiesis associated with an 11q23 translocation. Both patients received rhG-CSF after their cycles of chemotherapy and were considered for a bone marrow transplant. Marrow aspirates at frequent intervals showed gradual disappearance of the abnormal clone with parallel normalization of the peripheral count. In both patients G-CSF might have played a role in the development of the abnormal clone. We suggest that patients with therapy-related MDS without excess of blasts could be closely monitored for karyotypic and hematological improvement rather than transplanted immediately.
引用
收藏
页码:448 / 450
页数:3
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