The societal opportunities and challenges of genome editing

被引：41
作者：
Carroll, Dana [1 ]
Charo, R. Alta [2 ,3 ]
机构：
[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA
[2] Univ Wisconsin, Sch Law, Madison, WI 53706 USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Hist & Bioeth, Madison, WI 53706 USA
来源：
GENOME BIOLOGY | 2015年 / 16卷
关键词：
CRISPR-Cas; ethical issues; Food and Drug Administration; genetically engineered organism; germline genome editing; regulation; PROGRAMMABLE NUCLEASES; GENE-THERAPY; CRISPR-CAS9; MUTATIONS; RHESUS; MONKEY;
D O I：
10.1186/s13059-015-0812-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The genome editing platforms currently in use have revolutionized the field of genetics. At an accelerating rate, these tools are entering areas with direct impact on human well being. Here, we discuss applications in agriculture and in medicine, and examine some associated societal issues.
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页数：9
相关论文
共 46 条
[1]  
Anderson K., 2003, AgBioForum, V6, P95
[2]  
[Anonymous], SCI SEEK PERM GEN MO
[3]  
[Anonymous], 1997, NATL BIOETHICS ADVIS
[4]   Enabling plant synthetic biology through genome engineering [J].
Baltes, Nicholas J. ;
Voytas, Daniel F. .
TRENDS IN BIOTECHNOLOGY, 2015, 33 (02) :120-131
[5]   A prudent path forward for genomic engineering and germline gene modification [J].
Baltimore, David ;
Berg, Paul ;
Botchan, Michael ;
Carroll, Dana ;
Charo, R. Alta ;
Church, George ;
Corn, Jacob E. ;
Daley, George Q. ;
Doudna, Jennifer A. ;
Fenner, Marsha ;
Greely, Henry T. ;
Jinek, Martin ;
Martin, G. Steven ;
Penhoet, Edward ;
Puck, Jennifer ;
Sternberg, Samuel H. ;
Weissman, Jonathan S. ;
Yamamoto, Keith R. .
SCIENCE, 2015, 348 (6230) :36-38
[6]   Law, bioethics and practice in France: forging a new legislative pact [J].
Berthiau, Denis .
MEDICINE HEALTH CARE AND PHILOSOPHY, 2013, 16 (01) :105-113
[7]  
Brown Eric, 2004, New Atlantis, V5, P37
[8]   Site-specific selfish genes as tools for the control and genetic engineering of natural populations [J].
Burt, A .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2003, 270 (1518) :921-928
[9]   Genome Engineering with Targetable Nucleases [J].
Carroll, Dana .
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83, 2014, 83 :409-439
[10]  
Center for Genetics and Society, 2015, HUM GERML GEN ED
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