Developmental programming of hypothalamic neuroendocrine systems

被引：22

作者：

Ralevski, Alexandra ^{[1
]}

Horvath, Tamas L. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Comparat Med Sect, Program Integrat Cell Signaling & Neurobiol Metab, New Haven, CT 06510 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2015年 / 39卷

关键词：

Hypothalamus; Development; Metabolism; Complex behaviors; GESTATIONAL DIABETES-MELLITUS; POSTNATAL LEPTIN SURGE; CENTRAL-NERVOUS-SYSTEM; NEUROPEPTIDE-Y; FETAL ORIGINS; BODY-WEIGHT; OBESITY; NEURONS; PREGNANCY; MICE;

D O I：

10.1016/j.yfrne.2015.09.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is increasing evidence to suggest that the perinatal environment may alter the developmental programming of hypothalamic neuroendocrine systems in a manner that predisposes offspring to the development of metabolic syndrome. Although it is unclear how these effects might be mediated, it has been shown that changes in neuroendocrine programing during critical periods of development, either via maternal metabolic programming or other factors, can alter a fetus's metabolic fate. This review summarizes the hypothalamic circuits that mediate energy homeostasis and discusses the various factors that may influence the development and functioning of these neural systems, as well as the possible cognitive impairments that may arise as a result of these metabolic influences. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：52 / 58

页数：7

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