Glycaemic instability correlates with a hyperglucagonaemic response in patients with type 1 diabetes without residual beta-cell function

被引：10

作者：

Bessho, Megumi ^{[1
]}

Murase-Mishiba, Yuko ^{[1
]}

Tsutsumi, Chiharu ^{[1
]}

Haseda, Fumitaka ^{[1
]}

Imagawa, Akihisa ^{[2
]}

Terasaki, Jungo ^{[1
]}

Hanafusa, Toshiaki ^{[1
]}

机构：

[1] Osaka Med Coll, Dept Internal Med 1, Takatsuki, Osaka 5698686, Japan

[2] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka 5698686, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2013年 / 102卷 / 02期

关键词：

Glycaemic instability; Type; 1; diabetes; Glucagon; GLUCOSE VARIABILITY; HYPOGLYCEMIA; ADOLESCENTS; INSULIN;

D O I：

10.1016/j.diabres.2013.09.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the association between arginine-stimulated glucagon secretion (AUC(IRG)) and several parameters of glycaemic variability in 12 patients with type 1 diabetes without residual beta-cell function. AUC(IRG) positively correlated with the SD and mean amplitude of glycaemic excursions, thus glucagon might contribute to glycaemic instability, independent of endogenous insulin. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E38 / E40

页数：3

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