Enzyme-responsive reporter molecules for selective localization and fluorescence imaging of pathogenic biofilms

被引：41

作者：

Aw, Junxin ^{[1
]}

Widjaja, Frances ^{[1
]}

Ding, Yichen ^{[2
,3
]}

Mu, Jing ^{[1
]}

Liang, Yang ^{[2
]}

Xing, Bengang ^{[1
,4
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[2] Nanyang Technol Univ, Sch Biol Sci, Ctr Environm Life Sci Engn SCELSE, Singapore 637551, Singapore

[3] Nanyang Technol Univ, IGS, Singapore 639798, Singapore

[4] ASTAR, IMRE, Singapore 117602, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 23期

关键词：

BETA-LACTAMASE; LIVE-CELL; RESISTANT; PROBE; AGGREGATION; ANTIBIOTICS; INHIBITION; DESIGN;

D O I：

10.1039/c6cc09296a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pathogenic bacteria and their biofilm formation are responsible for a broad spectrum of microbial infections. A novel enzyme-responsive reporter molecule (ERM-1), which can specifically recognize AmpC beta-lactamase (Bla) in drug resistant bacteria, has been developed to enable the selective localization of biofilms.

引用

页码：3330 / 3333

页数：4

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