Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche

被引：85
作者：
Mondor, Isabelle [1 ]
Baratin, Myriam [1 ]
Lagueyrie, Marine [1 ]
Saro, Lisa [1 ]
Henri, Sandrine [1 ]
Gentek, Rebecca [1 ]
Suerinck, Delphine [1 ]
Kastenmuller, Wolfgang [2 ]
Jiang, Jean X. [3 ]
Bajenoff, Marc [1 ]
机构：
[1] Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France
[2] Univ Wurzburg, Inst Syst Immunol, D-97078 Wurzburg, Germany
[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX 78229 USA
来源：
IMMUNITY | 2019年 / 50卷 / 06期
基金：
欧洲研究理事会;
关键词：
TISSUE-RESIDENT MACROPHAGES; LANGERHANS CELLS; CARDIAC MACROPHAGES; FLUORESCENT PROTEIN; STEADY-STATE; SPI-C; MONOCYTES; ACTIVATION; MICE; MAINTENANCE;
D O I：
10.1016/j.immuni.2019.04.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In lymph nodes, subcapsular sinus macrophages (SSMs) form an immunological barrier that monitors lymph drained from peripheral tissues. Upon infection, SSMs activate B and natural killer T (NKT) cells while secreting inflammatory mediators. Here, we investigated the mechanisms regulating development and homeostasis of SSMs. Embryonic SSMs originated from yolk sac hematopoiesis and were replaced by a postnatal wave of bone marrow (BM)-derived monocytes that proliferated to establish the adult SSM network. The SSM network self-maintained by proliferation with minimal BM contribution. Upon pathogen-induced transient deletion, BM-derived cells contributed to restoring the SSM network. Lymphatic endothelial cells (LECs) were the main source of CSF-1 within the lymph node and conditional deletion of Csf1 in adult LECs decreased the network of SSMs and medullary sinus macrophages (MSMs). Thus, SSMs have a dual hematopoietic origin, and LECs are essential to the niche supporting these macrophages.
引用
收藏
页码：1453 / +
页数：18
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