Osthole improves aspects of spatial performance in ovariectomized rats

被引：25

作者：

Hsieh, MT

Hsieh, CL

Wang, WH

Chen, CS

Lin, CJ

Wu, CR

机构：

[1] China Med Univ, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan

[2] China Med Univ, Inst Chinese Med Sci, Taichung 404, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2004年 / 32卷 / 01期

关键词：

Cnidiuim monnieri; Umbelliferae; osthole; spatial performance; scopolamine; ovariectomized rats;

D O I：

10.1142/S0192415X04001758

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The present study was designed to investigate the ameliorating effects of Cnidiuim monnieri L. Cusson (CM) and osthole, a constituent of CM, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. CM improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. In addition, osthole (3 and 10 mg/kg, sc) improved the performance deficit in OVA rats. It (10 and 30 mug/brain, icv) also improved the performance deficit caused by SCOP in intact female rats, and at 30 mug/brain improved the deficit in OVA rats. However, osthole did not alter the latency swum to reach the visible target in SCOP-treated and OVA rats. Accordingly, we suggested that osthole is an active constituent of CM, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.

引用

页码：11 / 20

页数：10