Vinflunine in the treatment of relapsed metastatic urothelial cancer: A systematic review and meta-analysis of real-world series

被引：5

作者：

Bamias, Aristotelis ^{[1
]}

Hegele, Axel ^{[2
]}

Medioni, Jacques ^{[3
]}

Castellano, Daniel ^{[4
]}

Doni, Laura ^{[5
]}

Passalacqua, Rodolfo ^{[6
]}

Zagouri, Flora ^{[1
]}

Tzannis, Kimon ^{[1
]}

Hussain, Syed ^{[7
]}

Ullen, Anders ^{[8
]}

机构：

[1] Univ Athens, Natl & Kapodistrian Univ Athens, Dept Clin Therapeut, Alexandra Hosp, 80 Vas Sofias Ave, Athens 11528, Greece

[2] Univ Med Ctr, Dept Urol & Pediat Urol, Baldingerst, D-35033 Marburg, Germany

[3] Paris Descartes Univ, Ctr Essais Precoces Cancerol, Hop European Georges Pompidou, 20 Rue Leblanc, F-75015 Paris, France

[4] Hosp Univ 12 Octubre, Av Cordoba S-N, Madrid 28041, Spain

[5] Aienda Osped Careggi UO, Med Oncol, 3 Largo Brambilla, I-50134 Florence, Italy

[6] ASST Ist Ospitalieri, Oncol Dept, Viale Concordia 1, I-26100 Cremona, Italy

[7] Med Sch, Dept Oncol & Metab, Acad Unit Clin Oncol, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England

[8] Karolinska Univ Hosp, Theme Canc, Eugeniavagen 3,PO Backencanc, S-17176 Solna, Sweden

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2019年 / 140卷

基金：

英国医学研究理事会;

关键词：

Urothelial cancer; Vinflunine; Meta-analysis; Second-line; Metastatic; TRANSITIONAL-CELL CARCINOMA; PLATINUM-CONTAINING REGIMEN; RETROSPECTIVE ANALYSIS; 1ST-LINE CHEMOTHERAPY; SUPPORTIVE CARE; BLADDER-CANCER; OPEN-LABEL; MULTICENTER; TRACT; VINORELBINE;

D O I：

10.1016/j.critrevonc.2019.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Vinflunine (VFL) is approved in Europe as second-line treatment of metastatic urothelial cancer after failure of platinum-containing therapy. We performed a systematic review and meta-analysis of real-world data (RWD) to assess utilization, efficacy and safety of VFL. Methods: We performed a MEDLINE search for the period of 1/1/2000-31/8/2017. Full-length articles providing post-marketing RWD on VFL in patients failing previous chemotherapy were eligible. Interventional clinical trials were excluded. Results: Ten studies with 797 patients were identified. According to pooled REs analysis, overall response rate was 19%, most frequent, all-grade toxicities were fatigue (41%), constipation (39%), nausea/vomiting (25%), and most prevalent Grade 3-4 toxicities were neutropenia (13%), anaemia (9%), fatigue (8%). Median OS was comparable to results reported in recent randomized studies. Conclusion: Our findings confirm the efficacy and safety of VFL in an unselected population and support the use of VFL in the changing treatment paradigm of relapsed mUC.

引用

页码：80 / 87

页数：8

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