An Update on the Role of Adipose Tissues in Psoriasis

被引：43

作者：

Wong, Yisheng ^{[1
]}

Nakamizo, Satoshi ^{[2
]}

Tan, Kahbing J. ^{[2
]}

Kabashima, Kenji ^{[2
,3
]}

机构：

[1] Natl Skin Ctr, Singapore, Singapore

[2] ASTAR, Singapore Immunol Network, Skin Res Inst Singapore, Singapore, Singapore

[3] Kyoto Univ, Sch Med, Dept Dermatol, Kyoto, Japan

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

obesity; psoriasis; adipose tissue-obesity; adipokine cytokines; adipocyte; macrophage-cell; leptin; PRO-INFLAMMATORY CYTOKINES; ADIPONECTIN LEVELS; OBESITY; LEPTIN; SEVERITY; RESISTIN; ADIPOCYTES; ADIPOKINES; WHITE; ACCUMULATION;

D O I：

10.3389/fimmu.2019.01507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.

引用

页数：7

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